Detailed information of TA system TA091709

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): prlF-yhaV (relBE)/YhaV-PrlF
• Location: 2063727..2064568
• Replicon: chromosome
• Accession: NZ_CP025682
• Organism: Azoarcus pumilus strain SY39

Toxin (Protein)

• Gene name: yhaV
• Uniprot ID: -
• Locus tag: C0099_RS09940
• Protein ID: WP_102247286.1
• Coordinates: 2064053..2064568 (+)
• Length: 172 a.a.

Antitoxin (Protein)

• Gene name: prlF
• Uniprot ID: -
• Locus tag: C0099_RS09935
• Protein ID: WP_102247285.1
• Coordinates: 2063727..2064056 (+)
• Length: 110 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C0099_RS09910	2059118..2059723	-	606	WP_102247281.1	UbiX family flavin prenyltransferase	-
C0099_RS09915	2059898..2060827	+	930	WP_164084901.1	LysR family transcriptional regulator	-
C0099_RS09920	2060933..2061574	-	642	WP_199797593.1	DUF2959 domain-containing protein	-
C0099_RS09925	2061793..2062647	-	855	WP_102247283.1	serine protein kinase RIO	-
C0099_RS09930	2062644..2062886	-	243	WP_102247284.1	VF530 family protein	-
C0099_RS09935	2063727..2064056	+	330	WP_102247285.1	type II toxin-antitoxin system PrlF family antitoxin	Antitoxin
C0099_RS09940	2064053..2064568	+	516	WP_102247286.1	type II toxin-antitoxin system YhaV family toxin	Toxin
C0099_RS15875	2064518..2064685	-	168	Protein_1946	HNH endonuclease	-
C0099_RS09945	2064863..2065240	+	378	WP_102247287.1	type II toxin-antitoxin system RelE/ParE family toxin	-
C0099_RS09950	2065221..2065559	+	339	WP_102247288.1	helix-turn-helix domain-containing protein	-
C0099_RS09955	2065738..2066691	-	954	WP_102247289.1	HNH endonuclease	-
C0099_RS09960	2066695..2067078	-	384	WP_102247290.1	HIT domain-containing protein	-
C0099_RS09970	2067697..2069253	+	1557	WP_102247291.1	malonate decarboxylase subunit alpha	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin endonuclease, YhaV (16-152)

Antitoxin

• PrlF antitoxin (8-107)

Sequences

Toxin

Protein

• Length: 172 a.a.
• Molecular weight: 20033.65 Da
• Isoelectric Point: 10.0328

>T91709 WP_102247286.1 NZ_CP025682:2064053-2064568 [Azoarcus pumilus]
MSATEPEPLVIHGWTVFAHPLFLEQVDALARQVEVLARKDPVGYVRKNASKRLAAITRLAFDVIPQDPTRREYRQGGTLG
DDHKHWFRAKFFQQYRLFFRYHASSKVIVYAWVNDEDTKRAFESNDDAYRVFSKMLASGRPPDDWNQLLTQAREESARMR
ESFERTGAIRR

Nucleotide

• Length: 516 bp

>T91709 NZ_CP025682:2064053-2064568 [Azoarcus pumilus]
ATGAGCGCCACAGAACCCGAACCCTTGGTCATTCATGGATGGACCGTCTTCGCTCATCCGCTCTTCCTTGAACAGGTCGA
TGCGCTGGCGCGACAGGTCGAGGTGCTCGCACGCAAAGACCCGGTCGGTTACGTCAGGAAAAACGCCAGCAAGAGACTGG
CAGCCATCACCCGGCTCGCATTCGATGTCATCCCGCAGGATCCGACTCGTCGCGAGTACCGCCAGGGCGGCACGCTGGGT
GACGATCACAAACATTGGTTCCGGGCCAAGTTCTTCCAGCAGTATCGGCTCTTCTTCCGCTATCACGCCTCGAGCAAAGT
GATCGTATATGCCTGGGTGAACGACGAAGACACCAAGCGGGCCTTTGAAAGCAACGACGACGCCTACCGGGTTTTCAGCA
AGATGCTCGCGAGCGGGCGTCCGCCGGACGATTGGAATCAACTGCTGACGCAGGCGCGCGAAGAGTCAGCGCGGATGCGC
GAGTCGTTCGAGAGAACCGGAGCGATAAGACGATAA

Antitoxin

Protein

• Length: 110 a.a.
• Molecular weight: 11995.50 Da
• Isoelectric Point: 4.3461

>AT91709 WP_102247285.1 NZ_CP025682:2063727-2064056 [Azoarcus pumilus]
MTAPLEVESTLTDRYQTTVPETVRRALKLGKRDRIHYAIRPNGEVVLTRAVAPGDDDPVLGQFLGFLAADITRHPERLQS
LDSALVDRLQSLVGDIDVDLDAVLSADDE

Nucleotide

• Length: 330 bp

>AT91709 NZ_CP025682:2063727-2064056 [Azoarcus pumilus]
ATGACCGCACCCCTCGAAGTCGAATCTACCCTCACCGATCGCTACCAGACGACGGTACCCGAAACCGTTCGCCGCGCCCT
CAAACTGGGCAAGCGCGACAGGATTCACTACGCCATTCGCCCGAACGGAGAGGTCGTCTTGACGCGTGCAGTAGCGCCCG
GGGATGACGATCCAGTGCTCGGCCAGTTCCTCGGGTTTCTGGCGGCCGACATCACGCGCCATCCAGAGCGGTTGCAATCC
CTGGATTCCGCTCTGGTCGATCGACTCCAGTCCCTGGTTGGCGATATCGATGTCGATCTGGATGCAGTTCTTTCAGCGGA
CGATGAATGA