Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 237321..237930 Replicon chromosome
Accession NZ_CP025682
Organism Azoarcus pumilus strain SY39

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag C0099_RS01180 Protein ID WP_102245741.1
Coordinates 237619..237930 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag C0099_RS01175 Protein ID WP_199797667.1
Coordinates 237321..237539 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C0099_RS01155 232773..234392 + 1620 WP_102245736.1 urea ABC transporter permease subunit UrtB -
C0099_RS01160 234548..235756 + 1209 WP_102245737.1 urea ABC transporter permease subunit UrtC -
C0099_RS01165 235758..236597 + 840 WP_102245738.1 urea ABC transporter ATP-binding protein UrtD -
C0099_RS01170 236600..237295 + 696 WP_102245739.1 urea ABC transporter ATP-binding subunit UrtE -
C0099_RS01175 237321..237539 - 219 WP_199797667.1 helix-turn-helix domain-containing protein Antitoxin
C0099_RS01180 237619..237930 - 312 WP_102245741.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C0099_RS01185 238039..238626 - 588 WP_123785202.1 hypothetical protein -
C0099_RS01190 238728..238964 - 237 WP_102245743.1 antitoxin MazE family protein -
C0099_RS01195 239076..239927 - 852 WP_102245744.1 DNA ligase -
C0099_RS01200 240119..242272 - 2154 WP_102245745.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(44-99)

Antitoxin

Cro/C1-type helix-turn-helix domain

(15-50)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11468.07 Da        Isoelectric Point: 9.8618

>T91704 WP_102245741.1 NZ_CP025682:c237930-237619 [Azoarcus pumilus]
MLTVVETPLFQRQWPAYWTEEERGAFAAYIAEHPSAGDVVPESGGIRKVRWSRAGSGKSGGVRVIYFTRTAQGEIVLLTL
YAKARTDNISGAKLKEIRRALEE

Download         Length: 312 bp

>T91704 NZ_CP025682:c237930-237619 [Azoarcus pumilus]
ATGCTGACAGTCGTCGAGACGCCTCTCTTCCAACGCCAGTGGCCGGCATACTGGACTGAAGAGGAGCGAGGCGCCTTCGC
CGCCTATATCGCGGAGCACCCAAGCGCCGGGGATGTCGTGCCGGAATCCGGCGGTATCCGGAAGGTGCGCTGGAGCCGCG
CCGGATCTGGCAAGTCAGGCGGCGTGCGCGTGATCTATTTCACCCGTACGGCTCAGGGCGAGATCGTATTGCTCACCCTC
TACGCGAAGGCCAGAACCGACAACATCAGTGGCGCAAAGCTGAAGGAGATCCGCCGTGCCCTCGAAGAATAA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 7471.70 Da        Isoelectric Point: 12.1412

>AT91704 WP_199797667.1 NZ_CP025682:c237539-237321 [Azoarcus pumilus]
MKAGQLQVVTSPVIEARKKTGLSQSQFAALLGVSVRTLQGWEQGRKQPSGAARTLLAIASTNPQAVLAVAGK

Download         Length: 219 bp

>AT91704 NZ_CP025682:c237539-237321 [Azoarcus pumilus]
ATGAAGGCTGGCCAACTGCAGGTTGTCACTTCTCCGGTCATCGAGGCGCGCAAAAAGACCGGGCTGTCGCAGTCTCAGTT
CGCGGCGCTGCTGGGGGTTTCGGTGCGCACCCTGCAGGGCTGGGAGCAGGGCCGCAAGCAGCCCAGTGGTGCGGCCCGGA
CCCTGCTTGCGATTGCCAGCACCAACCCGCAGGCGGTGCTTGCGGTAGCTGGAAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References