Detailed information of TA system TA091687

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 111564..111833
• Replicon: plasmid pEA-1
• Accession: NZ_CP025677
• Organism: Escherichia albertii strain ChinaSP140150

Toxin (Protein)

• Gene name: hok
• Uniprot ID: P11895
• Locus tag: C0R48_RS25985
• Protein ID: WP_001312861.1
• Coordinates: 111675..111833 (+)
• Length: 53 a.a.

Antitoxin (RNA)

Gene name	sok
Locus tag	-
Coordinates	111564..111629 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C0R48_RS25960	107274..107801	+	528	WP_000290834.1	single-stranded DNA-binding protein	-
C0R48_RS25965	107859..108092	+	234	WP_000006003.1	DUF905 family protein	-
C0R48_RS25970	108153..110176	+	2024	Protein_122	ParB/RepB/Spo0J family partition protein	-
C0R48_RS25975	110245..110679	+	435	WP_000845953.1	conjugation system SOS inhibitor PsiB	-
C0R48_RS25980	110676..111395	+	720	WP_001276217.1	plasmid SOS inhibition protein A	-
-	111407..111631	+	225	NuclAT_0	-	-
-	111407..111631	+	225	NuclAT_0	-	-
-	111407..111631	+	225	NuclAT_0	-	-
-	111407..111631	+	225	NuclAT_0	-	-
C0R48_RS27190	111416..111595	-	180	WP_001309233.1	hypothetical protein	-
-	111564..111629	+	66	-	-	Antitoxin
C0R48_RS25985	111675..111833	+	159	WP_001312861.1	type I toxin-antitoxin system Hok family toxin	Toxin
C0R48_RS27395	112071..112448	-	378	Protein_127	hypothetical protein	-
C0R48_RS26005	112748..113044	+	297	WP_001272251.1	hypothetical protein	-
C0R48_RS26010	113155..113976	+	822	WP_001234445.1	DUF945 domain-containing protein	-
C0R48_RS26015	114273..114920	-	648	WP_015059008.1	transglycosylase SLT domain-containing protein	-
C0R48_RS26020	115197..115580	+	384	WP_000124981.1	relaxosome protein TraM	-
C0R48_RS26025	115771..116457	+	687	WP_015059009.1	PAS domain-containing protein	-
C0R48_RS26030	116551..116778	+	228	WP_001254386.1	conjugal transfer relaxosome protein TraY	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	floR / tet(A) / aph(6)-Id / aph(3'')-Ib / sul2 / aph(3')-IIa / oqxB / oqxA / blaCTX-M-55	-	1..129356	129356

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (8-48)

Sequences

Toxin

Protein

• Length: 53 a.a.
• Molecular weight: 6082.32 Da
• Isoelectric Point: 9.2584

>T91687 WP_001312861.1 NZ_CP025677:111675-111833 [Escherichia albertii]
MKLPRSSLVWCVLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK

Nucleotide

• Length: 159 bp

>T91687 NZ_CP025677:111675-111833 [Escherichia albertii]
ATGAAACTACCACGAAGTTCCCTTGTCTGGTGTGTGTTGATCGTGTGTCTCACACTGTTGATATTCACTTATCTGACACG
AAAATCGCTGTGCGAGATTCGTTACAGAGACGGACACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG

Antitoxin

Nucleotide

• Length: 66 bp

>AT91687 NZ_CP025677:111564-111629 [Escherichia albertii]
AGAAGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCAC

Structures

Toxin

• AlphaFold DB: P11895

Antitoxin