Detailed information of TA system TA091670

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 2333051..2333613
• Replicon: chromosome
• Accession: NZ_CP025676
• Organism: Escherichia albertii strain ChinaSP140150

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A7U8ZNU8
• Locus tag: C0R48_RS11825
• Protein ID: WP_000605679.1
• Coordinates: 2333051..2333329 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: C0R48_RS11830
• Protein ID: WP_000781369.1
• Coordinates: 2333329..2333613 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C0R48_RS11795	2329031..2329462	-	432	WP_059225291.1	peroxiredoxin OsmC	-
C0R48_RS11805	2329729..2329866	+	138	WP_000841563.1	stationary-phase-induced ribosome-associated protein	-
C0R48_RS11815	2330023..2331720	+	1698	WP_000433442.1	malate dehydrogenase	-
C0R48_RS11820	2331855..2332865	+	1011	WP_059274967.1	alcohol dehydrogenase AdhP	-
C0R48_RS11825	2333051..2333329	+	279	WP_000605679.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
C0R48_RS11830	2333329..2333613	+	285	WP_000781369.1	HigA family addiction module antidote protein	Antitoxin
C0R48_RS11835	2333841..2334494	-	654	WP_000045636.1	formate dehydrogenase-N subunit gamma	-
C0R48_RS11840	2334487..2335371	-	885	WP_001240583.1	formate dehydrogenase N subunit beta	-
C0R48_RS11845	2335384..2338431	-	3048	WP_102204023.1	formate dehydrogenase-N subunit alpha	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (4-92)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (3-81)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10533.10 Da
• Isoelectric Point: 7.3995

>T91670 WP_000605679.1 NZ_CP025676:2333051-2333329 [Escherichia albertii]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAASSLVDIDMPGYRLHPLSGDRDGIWAISVSGNWRITFEFVN
GDAYILDYEDYH

Nucleotide

• Length: 279 bp

>T91670 NZ_CP025676:2333051-2333329 [Escherichia albertii]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCACCGACTCGCTGTGATTGATGCTGCAAGCAGTCTTGTTGATATCGATATGCCCGGTTACCGACTAC
ACCCATTAAGCGGCGATCGCGATGGCATCTGGGCAATATCTGTATCAGGCAACTGGCGAATCACGTTTGAGTTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10371.06 Da
• Isoelectric Point: 8.8567

>AT91670 WP_000781369.1 NZ_CP025676:2333329-2333613 [Escherichia albertii]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVAQ

Nucleotide

• Length: 285 bp

>AT91670 NZ_CP025676:2333329-2333613 [Escherichia albertii]
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAACTGAACGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCAACGGCAAGCCGACTGTTGACCGGAAAAGCGGCTTTGACGCCAGAAATGGCGA
TTAAACTTTCCGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAATGCCTGGAGTCTGGCAGAGGCTGAG
AAAACGGTGGATGTGTCGCGGTTGCGCCGTCTGGTTGCGCAATAA

Structures

Toxin

• AlphaFold DB: A0A7U8ZNU8