Detailed information of TA system TA091659

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): prlF-yhaV (relBE)/YhaV-PrlF
• Location: 602300..603099
• Replicon: chromosome
• Accession: NZ_CP025676
• Organism: Escherichia albertii strain ChinaSP140150

Toxin (Protein)

• Gene name: yhaV
• Uniprot ID: S1NYM6
• Locus tag: C0R48_RS03110
• Protein ID: WP_000347251.1
• Coordinates: 602300..602764 (-)
• Length: 155 a.a.

Antitoxin (Protein)

• Gene name: prlF
• Uniprot ID: -
• Locus tag: C0R48_RS03115
• Protein ID: WP_059250714.1
• Coordinates: 602764..603099 (-)
• Length: 112 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C0R48_RS03075	597313..597747	-	435	WP_000948824.1	PTS sugar transporter subunit IIA	-
C0R48_RS03080	597765..598643	-	879	WP_001295548.1	PTS system mannose/fructose/sorbose family transporter subunit IID	-
C0R48_RS03085	598633..599400	-	768	WP_102203931.1	PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC	-
C0R48_RS03090	599411..599884	-	474	WP_001132991.1	PTS N-acetylgalactosamine transporter subunit IIB	-
C0R48_RS03095	599907..601187	-	1281	WP_059216469.1	tagatose-bisphosphate aldolase subunit KbaZ	-
C0R48_RS03105	601436..602245	+	810	WP_059250716.1	aga operon transcriptional regulator AgaR	-
C0R48_RS03110	602300..602764	-	465	WP_000347251.1	type II toxin-antitoxin system ribonuclease toxin YhaV	Toxin
C0R48_RS03115	602764..603099	-	336	WP_059250714.1	type II toxin-antitoxin system antitoxin PrlF	Antitoxin
C0R48_RS03120	603248..604819	-	1572	WP_025238276.1	galactarate dehydratase	-
C0R48_RS03125	605190..606524	+	1335	WP_025238277.1	galactarate/glucarate/glycerate transporter GarP	-
C0R48_RS03130	606540..607310	+	771	WP_025238278.1	2-dehydro-3-deoxyglucarate aldolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin endonuclease, YhaV (12-150)

Antitoxin

• PrlF antitoxin (14-110)

Sequences

Toxin

Protein

• Length: 155 a.a.
• Molecular weight: 17777.14 Da
• Isoelectric Point: 9.4947

>T91659 WP_000347251.1 NZ_CP025676:c602764-602300 [Escherichia albertii]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Nucleotide

• Length: 465 bp

>T91659 NZ_CP025676:c602764-602300 [Escherichia albertii]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGATGCTTTAGTTGC
CGAAGTCGAGGCATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCAGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA

Antitoxin

Protein

• Length: 112 a.a.
• Molecular weight: 12335.94 Da
• Isoelectric Point: 4.5392

>AT91659 WP_059250714.1 NZ_CP025676:c603099-602764 [Escherichia albertii]
MPANARSNAVLTTESKITIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Nucleotide

• Length: 336 bp

>AT91659 NZ_CP025676:c603099-602764 [Escherichia albertii]
ATGCCCGCTAATGCTCGCTCTAACGCTGTACTGACCACTGAATCAAAGATCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCTGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCGACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGACGATGAGAT
TGGCGACGACGAATAA

Structures

Toxin

• AlphaFold DB: A0A829CJ20