Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 176394..176651 Replicon chromosome
Accession NZ_CP025676
Organism Escherichia albertii strain ChinaSP140150

Toxin (Protein)


Gene name hokA Uniprot ID V0YDF1
Locus tag C0R48_RS00835 Protein ID WP_001135738.1
Coordinates 176499..176651 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokA
Locus tag -
Coordinates 176394..176442 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C0R48_RS00815 171624..172619 - 996 WP_059235567.1 acyltransferase -
C0R48_RS00820 172792..173091 + 300 WP_000979961.1 YsaB family lipoprotein -
C0R48_RS00825 173187..174098 + 912 WP_001168544.1 glycine--tRNA ligase subunit alpha -
C0R48_RS00830 174108..176177 + 2070 WP_059235569.1 glycine--tRNA ligase subunit beta -
- 176394..176442 - 49 - - Antitoxin
C0R48_RS00835 176499..176651 + 153 WP_001135738.1 type I toxin-antitoxin system toxin HokA Toxin
C0R48_RS00840 176839..177051 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
C0R48_RS00845 177334..177624 - 291 WP_000455794.1 HTH-type transcriptional regulator -
C0R48_RS00850 178047..178757 + 711 WP_002460072.1 DUF3053 domain-containing protein -
C0R48_RS00855 178810..179814 - 1005 WP_102203917.1 glyoxylate/hydroxypyruvate reductase GhrB -
C0R48_RS00860 179887..180546 - 660 WP_000747625.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(5-46)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5912.14 Da        Isoelectric Point: 7.7173

>T91656 WP_001135738.1 NZ_CP025676:176499-176651 [Escherichia albertii]
MPQKYRLLSLIVICFTLLFFTWMIRDSLCELHIKQGSYELAAFLACNLKE

Download         Length: 153 bp

>T91656 NZ_CP025676:176499-176651 [Escherichia albertii]
ATGCCGCAGAAATATAGATTGCTTTCTTTAATAGTGATTTGTTTCACGCTTTTATTTTTCACCTGGATGATAAGGGATTC
ACTGTGTGAATTGCATATTAAACAGGGGAGTTATGAGCTGGCGGCGTTTTTAGCCTGCAATTTGAAAGAGTAA

Antitoxin


Download         Length: 49 bp

>AT91656 NZ_CP025676:c176442-176394 [Escherichia albertii]
GCATAGAGGGGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LX93

Antitoxin

Download structure file

References