Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | DinJ-YafQ (relBE)/YafQ-DinJ |
Location | 1306524..1307088 | Replicon | chromosome |
Accession | NZ_CP025582 | ||
Organism | Lacticaseibacillus paracasei strain HD1.7 |
Toxin (Protein)
Gene name | yafQ | Uniprot ID | A0A510WIJ9 |
Locus tag | CWS34_RS07075 | Protein ID | WP_016363448.1 |
Coordinates | 1306786..1307088 (+) | Length | 101 a.a. |
Antitoxin (Protein)
Gene name | dinJ | Uniprot ID | K6SLT0 |
Locus tag | CWS34_RS07070 | Protein ID | WP_003570051.1 |
Coordinates | 1306524..1306793 (+) | Length | 90 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
CWS34_RS07040 | 1301529..1302416 | - | 888 | WP_003570041.1 | ABC transporter ATP-binding protein | - |
CWS34_RS07045 | 1302613..1303839 | - | 1227 | WP_003570043.1 | hypothetical protein | - |
CWS34_RS07050 | 1304037..1304441 | + | 405 | WP_003570045.1 | MerR family transcriptional regulator | - |
CWS34_RS07055 | 1304434..1304760 | + | 327 | WP_003584272.1 | YrdB family protein | - |
CWS34_RS07060 | 1304823..1305452 | + | 630 | WP_101512010.1 | DUF2399 domain-containing protein | - |
CWS34_RS07065 | 1305497..1306150 | + | 654 | WP_003570049.1 | GNAT family N-acetyltransferase | - |
CWS34_RS07070 | 1306524..1306793 | + | 270 | WP_003570051.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
CWS34_RS07075 | 1306786..1307088 | + | 303 | WP_016363448.1 | type II toxin-antitoxin system YafQ family toxin | Toxin |
CWS34_RS15990 | 1307427..1307570 | + | 144 | WP_162259784.1 | hypothetical protein | - |
CWS34_RS07080 | 1307688..1308380 | + | 693 | WP_003570055.1 | hypothetical protein | - |
CWS34_RS07085 | 1308616..1310793 | + | 2178 | WP_003570057.1 | RNA-binding transcriptional accessory protein | - |
CWS34_RS07090 | 1311218..1311775 | - | 558 | WP_003584278.1 | helix-turn-helix domain-containing protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 101 a.a. Molecular weight: 11510.33 Da Isoelectric Point: 9.8881
>T90624 WP_016363448.1 NZ_CP025582:1306786-1307088 [Lacticaseibacillus paracasei]
MYSLVPTPTFKRDLKRLSKKHWPMDELKTAVNLLAAGTNAELLSKKYADHALSSSSEWKGYRELYVDGPRGDWLLIYKIE
QQDLILTLVRTGSHHNLLVK
MYSLVPTPTFKRDLKRLSKKHWPMDELKTAVNLLAAGTNAELLSKKYADHALSSSSEWKGYRELYVDGPRGDWLLIYKIE
QQDLILTLVRTGSHHNLLVK
Download Length: 303 bp
>T90624 NZ_CP025582:1306786-1307088 [Lacticaseibacillus paracasei]
ATGTATAGTCTGGTTCCGACGCCTACATTTAAGCGCGATCTAAAACGACTCTCCAAGAAGCATTGGCCGATGGACGAACT
AAAGACGGCTGTTAATCTCCTAGCCGCTGGTACAAATGCTGAACTATTAAGCAAAAAGTATGCAGATCATGCCTTGTCCT
CAAGCAGCGAGTGGAAAGGATATCGTGAACTATATGTTGACGGCCCTCGTGGCGACTGGTTGCTAATCTATAAAATTGAG
CAGCAAGATCTTATTTTAACCCTAGTTAGAACCGGATCTCATCATAACCTTCTGGTTAAATAG
ATGTATAGTCTGGTTCCGACGCCTACATTTAAGCGCGATCTAAAACGACTCTCCAAGAAGCATTGGCCGATGGACGAACT
AAAGACGGCTGTTAATCTCCTAGCCGCTGGTACAAATGCTGAACTATTAAGCAAAAAGTATGCAGATCATGCCTTGTCCT
CAAGCAGCGAGTGGAAAGGATATCGTGAACTATATGTTGACGGCCCTCGTGGCGACTGGTTGCTAATCTATAAAATTGAG
CAGCAAGATCTTATTTTAACCCTAGTTAGAACCGGATCTCATCATAACCTTCTGGTTAAATAG
Antitoxin
Download Length: 90 a.a. Molecular weight: 9982.68 Da Isoelectric Point: 7.2026
>AT90624 WP_003570051.1 NZ_CP025582:1306524-1306793 [Lacticaseibacillus paracasei]
MAATKKETRLNIRVDPELKSAAQIVANDMGIDLTAAVTMFMTKMVKDHALPFTPTSLPVETLQALKEAKHPELLKKYSTP
DDMWRDLNV
MAATKKETRLNIRVDPELKSAAQIVANDMGIDLTAAVTMFMTKMVKDHALPFTPTSLPVETLQALKEAKHPELLKKYSTP
DDMWRDLNV
Download Length: 270 bp
>AT90624 NZ_CP025582:1306524-1306793 [Lacticaseibacillus paracasei]
ATGGCAGCCACAAAGAAGGAAACTCGCTTGAATATTCGTGTTGATCCTGAATTAAAAAGTGCTGCTCAAATCGTAGCAAA
TGATATGGGCATCGACTTGACCGCAGCTGTTACGATGTTCATGACGAAAATGGTGAAAGATCACGCCCTCCCGTTTACCC
CAACAAGTCTACCAGTTGAAACCTTACAGGCGCTGAAAGAAGCAAAGCACCCAGAGCTGCTCAAAAAATACAGCACGCCT
GATGACATGTGGAGAGACTTGAATGTATAG
ATGGCAGCCACAAAGAAGGAAACTCGCTTGAATATTCGTGTTGATCCTGAATTAAAAAGTGCTGCTCAAATCGTAGCAAA
TGATATGGGCATCGACTTGACCGCAGCTGTTACGATGTTCATGACGAAAATGGTGAAAGATCACGCCCTCCCGTTTACCC
CAACAAGTCTACCAGTTGAAACCTTACAGGCGCTGAAAGAAGCAAAGCACCCAGAGCTGCTCAAAAAATACAGCACGCCT
GATGACATGTGGAGAGACTTGAATGTATAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A510WIJ9 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0E2BRK6 |