Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 2094874..2095328 Replicon chromosome
Accession NZ_CP025570
Organism Acidipropionibacterium jensenii strain JS280

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag C0Z10_RS09425 Protein ID WP_097799906.1
Coordinates 2095170..2095328 (-) Length 53 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag C0Z10_RS09420 Protein ID WP_201270187.1
Coordinates 2094874..2095128 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C0Z10_RS09390 2090146..2090745 - 600 WP_097799195.1 histone deacetylase -
C0Z10_RS09395 2090762..2092642 - 1881 WP_201270186.1 ABC transporter ATP-binding protein/permease -
C0Z10_RS09400 2092686..2093240 - 555 WP_127822683.1 hypothetical protein -
C0Z10_RS09405 2093288..2093827 - 540 WP_097799198.1 GNAT family N-acetyltransferase -
C0Z10_RS09410 2094077..2094331 - 255 WP_097799199.1 Txe/YoeB family addiction module toxin -
C0Z10_RS09415 2094332..2094592 - 261 WP_028702687.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
C0Z10_RS09420 2094874..2095128 - 255 WP_201270187.1 HigA family addiction module antidote protein Antitoxin
C0Z10_RS09425 2095170..2095328 - 159 WP_097799906.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C0Z10_RS09430 2095532..2096674 - 1143 WP_097799200.1 phage major capsid protein -
C0Z10_RS09435 2096888..2097385 - 498 WP_097799201.1 hypothetical protein -
C0Z10_RS09440 2097715..2098068 - 354 WP_097799202.1 WhiB family transcriptional regulator -
C0Z10_RS09445 2098290..2098751 - 462 WP_097799203.1 hypothetical protein -
C0Z10_RS09450 2098748..2098981 - 234 WP_097799204.1 hypothetical protein -
C0Z10_RS09455 2098995..2099282 - 288 WP_097799205.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(17-52)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(2-81)


Sequences

Toxin        


Download         Length: 53 a.a.        Molecular weight: 5658.14 Da        Isoelectric Point: 6.7100

>T90560 WP_097799906.1 NZ_CP025570:c2095328-2095170 [Acidipropionibacterium jensenii]
IGSGTRSSSGLTSSVHDGDRRGQHSIRINAQWRLCFVWGEGGADSVELVDYH

Download         Length: 159 bp

>T90560 NZ_CP025570:c2095328-2095170 [Acidipropionibacterium jensenii]
ATCGGTAGCGGAACCCGGTCGAGTTCCGGTTTAACGTCTAGCGTTCATGACGGTGACCGTCGTGGTCAGCACAGCATCCG
CATCAACGCGCAATGGCGTCTCTGCTTCGTCTGGGGAGAGGGAGGTGCGGACAGTGTCGAACTCGTCGACTACCACTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9596.03 Da        Isoelectric Point: 9.8887

>AT90560 WP_201270187.1 NZ_CP025570:c2095128-2094874 [Acidipropionibacterium jensenii]
MEDFIEGFGITQNKLAVSIGVPPRRINEIVHGKRGITADTAIRLARYFGTSEEFWMNLQSNYELRMERRALRDTVASITP
LRVA

Download         Length: 255 bp

>AT90560 NZ_CP025570:c2095128-2094874 [Acidipropionibacterium jensenii]
ATGGAGGATTTCATCGAGGGCTTCGGGATCACGCAGAACAAGCTCGCGGTGTCGATCGGCGTTCCGCCGCGGCGAATCAA
CGAGATTGTGCACGGCAAGCGTGGCATCACTGCGGACACGGCGATCCGGCTGGCGCGGTACTTCGGGACGTCCGAGGAGT
TCTGGATGAACCTGCAATCGAACTACGAGTTGCGCATGGAGCGGCGTGCACTGCGGGACACCGTCGCGTCAATCACACCA
CTGCGGGTCGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References