Detailed information of TA system TA090559

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-YefM
• Location: 2094077..2094592
• Replicon: chromosome
• Accession: NZ_CP025570
• Organism: Acidipropionibacterium jensenii strain JS280

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: C0Z10_RS09410
• Protein ID: WP_097799199.1
• Coordinates: 2094077..2094331 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: A0A3S4UWW3
• Locus tag: C0Z10_RS09415
• Protein ID: WP_028702687.1
• Coordinates: 2094332..2094592 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C0Z10_RS09380	2089158..2089685	-	528	WP_201270069.1	methylated-DNA--[protein]-cysteine S-methyltransferase	-
C0Z10_RS09385	2089682..2090059	-	378	WP_097799194.1	DUF1801 domain-containing protein	-
C0Z10_RS09390	2090146..2090745	-	600	WP_097799195.1	histone deacetylase	-
C0Z10_RS09395	2090762..2092642	-	1881	WP_201270186.1	ABC transporter ATP-binding protein/permease	-
C0Z10_RS09400	2092686..2093240	-	555	WP_127822683.1	hypothetical protein	-
C0Z10_RS09405	2093288..2093827	-	540	WP_097799198.1	GNAT family N-acetyltransferase	-
C0Z10_RS09410	2094077..2094331	-	255	WP_097799199.1	Txe/YoeB family addiction module toxin	Toxin
C0Z10_RS09415	2094332..2094592	-	261	WP_028702687.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
C0Z10_RS09420	2094874..2095128	-	255	WP_201270187.1	HigA family addiction module antidote protein	-
C0Z10_RS09425	2095170..2095328	-	159	WP_097799906.1	type II toxin-antitoxin system RelE/ParE family toxin	-
C0Z10_RS09430	2095532..2096674	-	1143	WP_097799200.1	phage major capsid protein	-
C0Z10_RS09435	2096888..2097385	-	498	WP_097799201.1	hypothetical protein	-
C0Z10_RS09440	2097715..2098068	-	354	WP_097799202.1	WhiB family transcriptional regulator	-
C0Z10_RS09445	2098290..2098751	-	462	WP_097799203.1	hypothetical protein	-
C0Z10_RS09450	2098748..2098981	-	234	WP_097799204.1	hypothetical protein	-
C0Z10_RS09455	2098995..2099282	-	288	WP_097799205.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-70)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9914.25 Da
• Isoelectric Point: 8.0424

>T90559 WP_097799199.1 NZ_CP025570:c2094331-2094077 [Acidipropionibacterium jensenii]
VRLVWDPSAWEDYTHWQTTDRRVLKRINTLIGSCLREPFAGIGKPEQLKYGAQGAWSRRITDEHRLVYLVDGDDLVILQA
RYHY

Nucleotide

• Length: 255 bp

>T90559 NZ_CP025570:c2094331-2094077 [Acidipropionibacterium jensenii]
GTGCGGCTGGTCTGGGACCCGTCTGCATGGGAGGACTACACACACTGGCAGACCACCGATCGTCGCGTGCTGAAGCGAAT
CAACACGCTCATCGGCTCCTGCCTTCGTGAGCCGTTCGCGGGTATCGGGAAACCGGAGCAGTTGAAGTATGGCGCGCAGG
GGGCATGGTCGCGCCGTATCACCGATGAGCACCGGCTGGTGTATCTCGTCGACGGGGACGACCTCGTGATCCTCCAGGCC
CGCTACCACTACTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9780.93 Da
• Isoelectric Point: 4.8839

>AT90559 WP_028702687.1 NZ_CP025570:c2094592-2094332 [Acidipropionibacterium jensenii]
MSISASEARRTLFPLIERINEDREAIEIVSRKGNAVLMPADEYTAWQETAYLFRSPANARRLLDAYERARAGKVETHALD
RADEDA

Nucleotide

• Length: 261 bp

>AT90559 NZ_CP025570:c2094592-2094332 [Acidipropionibacterium jensenii]
ATGTCTATCAGTGCCAGCGAGGCGCGCAGGACGCTGTTCCCGCTCATTGAGCGCATCAATGAAGACCGCGAGGCCATCGA
GATCGTCTCCCGCAAGGGCAACGCAGTGTTGATGCCCGCCGACGAGTACACGGCCTGGCAGGAGACGGCCTATCTGTTCC
GCTCACCTGCGAATGCTCGGCGACTGCTCGATGCCTACGAGCGTGCCCGCGCTGGGAAGGTCGAGACGCATGCCCTCGAC
CGTGCGGACGAGGATGCTTGA

Structures

Antitoxin

• AlphaFold DB: A0A3S4UWW3