Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1659556..1660217 Replicon chromosome
Accession NZ_CP025546
Organism Mycobacterium paragordonae strain 49061

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag C0J29_RS07730 Protein ID WP_120794621.1
Coordinates 1659882..1660217 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag C0J29_RS07725 Protein ID WP_120791936.1
Coordinates 1659556..1659885 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C0J29_RS07700 1655166..1656371 - 1206 WP_120791932.1 RtcB family protein -
C0J29_RS07710 1656830..1657768 - 939 WP_120791933.1 abortive infection family protein -
C0J29_RS07715 1658054..1658830 - 777 WP_120791934.1 TIGR02391 family protein -
C0J29_RS07720 1658875..1659489 - 615 WP_162951406.1 hypothetical protein -
C0J29_RS07725 1659556..1659885 - 330 WP_120791936.1 XRE family transcriptional regulator Antitoxin
C0J29_RS07730 1659882..1660217 - 336 WP_120794621.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C0J29_RS07735 1660282..1661610 - 1329 WP_120791937.1 site-specific integrase -
C0J29_RS07740 1661607..1661795 - 189 WP_120791938.1 helix-turn-helix domain-containing protein -
C0J29_RS07745 1662151..1663386 + 1236 WP_120791939.1 IS21 family transposase -
C0J29_RS07750 1663386..1664183 + 798 WP_084023409.1 IS21-like element helper ATPase IstB -
C0J29_RS07755 1664194..1664826 - 633 WP_120791940.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1601134..1676902 75768


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(10-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-94)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12492.23 Da        Isoelectric Point: 4.3961

>T90548 WP_120794621.1 NZ_CP025546:c1660217-1659882 [Mycobacterium paragordonae]
VILLDEVETWYFALDDEAVAAVTGAIDLLELEGPTLGRPTVDKVKGSKFHSMKELRPAGTSIRILFIFDPERQAILLLGG
DKAGNWKSWYDKNIPIAEQRYEKWLATEEGD

Download         Length: 336 bp

>T90548 NZ_CP025546:c1660217-1659882 [Mycobacterium paragordonae]
GTGATCTTGCTAGACGAGGTCGAGACCTGGTACTTCGCGCTTGACGATGAAGCGGTAGCCGCCGTTACCGGCGCTATCGA
CCTGCTCGAACTCGAAGGGCCCACCCTCGGCCGTCCAACGGTGGACAAGGTCAAGGGATCCAAGTTTCACAGCATGAAGG
AGCTGCGGCCAGCCGGCACGAGCATCCGAATCCTGTTTATCTTTGATCCTGAGCGACAAGCGATCCTGCTGCTTGGTGGC
GATAAGGCAGGCAACTGGAAAAGCTGGTACGACAAGAACATCCCGATAGCTGAGCAGCGCTACGAGAAGTGGCTCGCGAC
CGAGGAAGGTGATTGA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11781.37 Da        Isoelectric Point: 8.7207

>AT90548 WP_120791936.1 NZ_CP025546:c1659885-1659556 [Mycobacterium paragordonae]
MKVARNWREIRADAIAQGRLDPSRAEAARKEMHDAVQAQRLTDIRKAHGLVRQADVAALMGVSQARISKLESGDLSHTEL
GTLQSYVAALGGSLRIVAEFGESTVELTG

Download         Length: 330 bp

>AT90548 NZ_CP025546:c1659885-1659556 [Mycobacterium paragordonae]
TTGAAGGTGGCACGAAACTGGCGTGAGATTCGAGCGGATGCCATCGCGCAGGGGCGACTGGATCCGTCCCGCGCCGAGGC
CGCCCGCAAGGAAATGCATGACGCCGTCCAGGCCCAACGTCTCACTGACATACGTAAGGCGCACGGCCTCGTCCGCCAGG
CTGATGTCGCTGCCCTTATGGGCGTATCTCAGGCGCGGATATCGAAATTGGAGAGCGGGGACCTGTCGCACACCGAGCTG
GGCACGCTGCAGTCCTATGTGGCGGCGCTGGGCGGGAGCCTGCGAATTGTGGCCGAGTTTGGCGAGAGCACGGTAGAGCT
GACCGGATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References