Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 1497178..1497833 Replicon chromosome
Accession NZ_CP025531
Organism Bordetella pertussis strain I955

Toxin (Protein)


Gene name mqsR Uniprot ID -
Locus tag CG027_RS07350 Protein ID WP_047122780.1
Coordinates 1497178..1497429 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID Q7VY40
Locus tag CG027_RS07355 Protein ID WP_003809516.1
Coordinates 1497432..1497833 (+) Length 134 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CG027_RS07325 1492339..1493469 - 1131 WP_010930401.1 helix-turn-helix transcriptional regulator -
CG027_RS07330 1493704..1494285 + 582 WP_019247931.1 molybdenum cofactor biosysynthesis protein -
CG027_RS07335 1494422..1495486 + 1065 WP_003809510.1 fructose-bisphosphate aldolase class II -
CG027_RS07340 1495571..1496017 - 447 WP_003819827.1 GFA family protein -
CG027_RS07345 1496242..1497123 + 882 WP_003809513.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
CG027_RS07350 1497178..1497429 + 252 WP_047122780.1 type II toxin-antitoxin system MqsR family toxin Toxin
CG027_RS07355 1497432..1497833 + 402 WP_003809516.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
CG027_RS07360 1497853..1498089 + 237 WP_010930404.1 membrane protein -
CG027_RS07365 1498097..1498576 + 480 WP_010930405.1 disulfide bond formation protein B -
CG027_RS07370 1498726..1499241 + 516 WP_019247930.1 5-(carboxyamino)imidazole ribonucleotide mutase -
CG027_RS07375 1499244..1500434 + 1191 WP_010930406.1 5-(carboxyamino)imidazole ribonucleotide synthase -
CG027_RS07380 1500454..1501491 + 1038 WP_023853543.1 threonylcarbamoyl-AMP synthase -
CG027_RS07385 1501628..1502650 + 1023 WP_003809532.1 amino acid ABC transporter substrate-binding protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(10-82)

Antitoxin

(1-131)


Sequences


Toxin        


Download         Length: 84 a.a.        Molecular weight: 8952.52 Da        Isoelectric Point: 9.7242

>T90524 WP_047122780.1 NZ_CP025531:1497178-1497429 [Bordetella pertussis]
IGGAATKKPGQKRRAGAAALGLDFSAMVEIVLALTPRDFHKSMTTHADHRIWQDVYCPVTAMGAVYLKLTVLDGVPIVSF
KEL

Download         Length: 252 bp

>T90524 NZ_CP025531:1497178-1497429 [Bordetella pertussis]
ATTGGAGGCGCGGCGACAAAAAAGCCGGGACAAAAGCGTCGCGCCGGGGCGGCGGCGCTGGGGCTGGATTTCAGCGCCAT
GGTCGAAATCGTGCTTGCATTGACACCGCGGGATTTCCACAAAAGCATGACTACCCATGCCGACCATCGCATTTGGCAGG
ACGTCTATTGCCCGGTGACAGCGATGGGCGCCGTCTACCTGAAGCTGACGGTCCTCGACGGCGTGCCGATCGTGTCGTTC
AAGGAGTTGTGA

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14528.70 Da        Isoelectric Point: 8.5005

>AT90524 WP_003809516.1 NZ_CP025531:1497432-1497833 [Bordetella pertussis]
MKCPVCGAAALARDTRDVPYSYKGETITIAAVTGDWCPACGENVLDGAESARVSEAMLAFNRLVNARRVDPGFIVRVRRK
LGLDQREAAALFGGGTNAFSRYENGKTRPPLALVKLLRLLDRHPELLEEVRAD

Download         Length: 402 bp

>AT90524 NZ_CP025531:1497432-1497833 [Bordetella pertussis]
ATGAAGTGTCCCGTATGCGGAGCGGCCGCGCTGGCGCGTGATACTCGCGATGTGCCCTATAGCTACAAGGGCGAGACCAT
CACGATTGCGGCGGTGACGGGCGACTGGTGTCCGGCATGCGGCGAGAACGTGCTCGATGGCGCTGAATCGGCGCGGGTGA
GCGAGGCCATGCTGGCTTTCAACCGCCTGGTCAACGCCCGCCGCGTCGACCCCGGGTTCATCGTGCGGGTGCGCAGGAAG
CTGGGGCTGGACCAGCGCGAAGCCGCGGCGCTGTTCGGCGGCGGCACCAATGCGTTCTCGCGTTACGAGAACGGCAAGAC
GCGCCCGCCGCTGGCGCTGGTGAAGCTGCTCAGGCTGCTGGATCGCCATCCGGAGCTGCTGGAGGAAGTCCGTGCGGATT
GA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A0H3LKS6

References