Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ldrD-rdlD/Ldr(toxin)
Location 78525..78747 Replicon chromosome
Accession NZ_CP025520
Organism Escherichia coli strain DH5alpha

Toxin (Protein)


Gene name ldrD Uniprot ID D3H2K1
Locus tag CDN75_RS00525 Protein ID WP_000170955.1
Coordinates 78525..78632 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name rdlD
Locus tag -
Coordinates 78680..78747 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDN75_RS00490 74381..75214 + 834 WP_000456467.1 peptide chain release factor N(5)-glutamine methyltransferase -
CDN75_RS00495 75211..75603 + 393 WP_000200374.1 invasion regulator SirB2 -
CDN75_RS00500 75607..76416 + 810 WP_001257044.1 invasion regulator SirB1 -
CDN75_RS00505 76452..77306 + 855 WP_046613400.1 3-deoxy-8-phosphooctulonate synthase -
CDN75_RS00510 77455..77562 - 108 WP_000170955.1 small toxic polypeptide LdrA/LdrC -
CDN75_RS00515 77990..78097 - 108 WP_000170963.1 small toxic polypeptide LdrB -
CDN75_RS00525 78525..78632 - 108 WP_000170955.1 small toxic polypeptide LdrA/LdrC Toxin
- 78680..78747 + 68 - - Antitoxin
CDN75_RS00530 79036..80136 - 1101 WP_000063607.1 sodium-potassium/proton antiporter ChaA -
CDN75_RS00535 80406..80636 + 231 WP_001146444.1 putative cation transport regulator ChaB -
CDN75_RS00540 80794..81489 + 696 WP_001336325.1 glutathione-specific gamma-glutamylcyclotransferase -
CDN75_RS00545 81533..81886 - 354 WP_001169669.1 DsrE/F sulfur relay family protein YchN -
CDN75_RS00550 82071..83465 + 1395 WP_000086217.1 inverse autotransporter invasin YchO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)


Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4013.82 Da        Isoelectric Point: 11.4779

>T90470 WP_000170955.1 NZ_CP025520:c78632-78525 [Escherichia coli]
MTLAQFAMIFWHDLAAPILAGIITAAIVSWWRNRK

Download         Length: 108 bp

>T90470 NZ_CP025520:c78632-78525 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 68 bp

>AT90470 NZ_CP025520:78680-78747 [Escherichia coli]
GTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829J2A9

Antitoxin

Download structure file

References