Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 533325..533940 Replicon chromosome
Accession NZ_CP025512
Organism Neorhizobium sp. SOG26

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag CYG48_RS02515 Protein ID WP_118848936.1
Coordinates 533325..533621 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag CYG48_RS02520 Protein ID WP_118848937.1
Coordinates 533632..533940 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CYG48_RS02500 528521..530173 - 1653 WP_118848933.1 choline dehydrogenase -
CYG48_RS02505 530184..531647 - 1464 WP_118848934.1 betaine-aldehyde dehydrogenase -
CYG48_RS02510 531659..533176 - 1518 WP_118848935.1 choline-sulfatase -
CYG48_RS02515 533325..533621 + 297 WP_118848936.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CYG48_RS02520 533632..533940 + 309 WP_118848937.1 HigA family addiction module antidote protein Antitoxin
CYG48_RS02525 534050..535051 + 1002 WP_199925194.1 NAD(P)H-quinone oxidoreductase -
CYG48_RS02530 535578..535724 + 147 WP_118848938.1 DUF1127 domain-containing protein -
CYG48_RS02535 535794..536531 - 738 WP_118851453.1 DUF3750 domain-containing protein -
CYG48_RS02540 536622..537629 + 1008 WP_118848939.1 asparaginase -
CYG48_RS02545 537699..538322 + 624 WP_118848940.1 glutathione S-transferase family protein -
CYG48_RS02550 538332..538541 - 210 WP_118848941.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-70)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11770.31 Da        Isoelectric Point: 8.0650

>T90458 WP_118848936.1 NZ_CP025512:533325-533621 [Neorhizobium sp. SOG26]
MITGFRDTWLHDFFVLDKRNKRIPADIENRLFRKIQMIDDAVSDQDLRVPPSNHFEKLRGSLDGFCSIRVNRQWRLVFRW
DGARGEASELYLDDHSYR

Download         Length: 297 bp

>T90458 NZ_CP025512:533325-533621 [Neorhizobium sp. SOG26]
ATGATCACAGGCTTCCGGGACACATGGCTCCACGACTTCTTTGTTCTCGACAAGCGGAACAAGAGGATCCCGGCCGACAT
CGAAAACAGGTTGTTTCGCAAGATCCAGATGATCGACGATGCGGTCAGCGACCAGGACCTGCGGGTGCCGCCCAGCAACC
ACTTCGAGAAGCTTCGCGGGTCGTTGGATGGCTTCTGTTCGATCCGCGTGAACAGGCAATGGCGGTTGGTCTTCCGATGG
GATGGAGCAAGAGGCGAGGCCTCGGAACTCTATCTCGATGACCATAGCTATAGATGA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11464.38 Da        Isoelectric Point: 10.5835

>AT90458 WP_118848937.1 NZ_CP025512:533632-533940 [Neorhizobium sp. SOG26]
VLMTKRKPASVGEILVSEFMEPMGLTQTALAEAMGVPRKHVNELCNDRRAVTAPTALILARVFGNSPDFWLNIQRRTELW
AAMNDPKEVQRIDRARPIHKAA

Download         Length: 309 bp

>AT90458 NZ_CP025512:533632-533940 [Neorhizobium sp. SOG26]
GTGTTGATGACGAAGCGAAAGCCCGCCTCTGTCGGAGAAATCCTGGTGAGCGAATTCATGGAGCCGATGGGGCTGACGCA
GACGGCGCTGGCCGAGGCCATGGGCGTTCCGCGCAAACATGTAAACGAGCTGTGCAACGACCGTCGCGCGGTCACTGCAC
CGACAGCGCTTATCCTTGCGCGGGTTTTCGGAAACAGCCCGGACTTCTGGCTCAATATCCAGCGCCGGACGGAGCTTTGG
GCGGCGATGAATGATCCAAAGGAAGTGCAGCGGATCGACCGTGCGCGACCCATCCACAAGGCTGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References