Detailed information of TA system TA090443

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 2154477..2154815
• Replicon: chromosome
• Accession: NZ_CP025495
• Organism: Staphylococcus aureus strain 3020.C01

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: A7U46_RS11195
• Protein ID: WP_011447039.1
• Coordinates: 2154477..2154653 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	2154641..2154815 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A7U46_RS11175	2149712..2153497	+	3786	WP_000582165.1	hypothetical protein	-
A7U46_RS11180	2153487..2153639	+	153	WP_001153681.1	hypothetical protein	-
A7U46_RS11185	2153686..2153973	+	288	WP_001040261.1	hypothetical protein	-
A7U46_RS11190	2154031..2154327	+	297	WP_000539688.1	DUF2951 domain-containing protein	-
A7U46_RS11195	2154477..2154653	+	177	WP_011447039.1	putative holin-like toxin	Toxin
-	2154641..2154815	-	175	-	-	Antitoxin
A7U46_RS11205	2154865..2155119	+	255	WP_000611512.1	phage holin	-
A7U46_RS11210	2155131..2155886	+	756	WP_000861038.1	CHAP domain-containing protein	-
A7U46_RS11215	2156077..2156568	+	492	WP_000919350.1	staphylokinase	-
A7U46_RS11225	2157218..2157553	+	336	Protein_2102	SH3 domain-containing protein	-
A7U46_RS11230	2157648..2158097	-	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
A7U46_RS11235	2158782..2159132	+	351	WP_000702263.1	complement inhibitor SCIN-A	-
A7U46_RS11240	2159185..2159445	-	261	WP_001791826.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	hlb / sak / chp / scn / hlb / map	2114133..2162948	48815

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T90443 WP_011447039.1 NZ_CP025495:2154477-2154653 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T90443 NZ_CP025495:2154477-2154653 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 175 bp

>AT90443 NZ_CP025495:c2154815-2154641 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• PDB: 7NS1

Antitoxin