Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 3029978..3031221 Replicon chromosome
Accession NZ_CP025491
Organism Legionella sainthelensi strain LA01-117

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag CAB17_RS13365 Protein ID WP_101898596.1
Coordinates 3030283..3031221 (+) Length 313 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID -
Locus tag CAB17_RS13360 Protein ID WP_101898595.1
Coordinates 3029978..3030286 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CAB17_RS13335 3025418..3025645 + 228 WP_101898590.1 helix-turn-helix transcriptional regulator -
CAB17_RS13340 3025632..3026852 + 1221 WP_101898591.1 type II toxin-antitoxin system HipA family toxin -
CAB17_RS13345 3027110..3028621 + 1512 WP_101898592.1 Fic family protein -
CAB17_RS13350 3028658..3029365 + 708 WP_101898593.1 hypothetical protein -
CAB17_RS13355 3029754..3029981 + 228 WP_101898594.1 helix-turn-helix transcriptional regulator -
CAB17_RS13360 3029978..3030286 + 309 WP_101898595.1 HipA N-terminal domain-containing protein Antitoxin
CAB17_RS13365 3030283..3031221 + 939 WP_101898596.1 lpg2370 family Dot/Icm T4SS effector Toxin
CAB17_RS13370 3031310..3031495 - 186 Protein_2612 integrase -
CAB17_RS13375 3031917..3033647 + 1731 WP_101898597.1 hypothetical protein -
CAB17_RS13380 3033914..3035284 - 1371 WP_129556899.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(53-276)

Antitoxin

HipA, N-terminal subdomain 1

(5-98)


Sequences

Toxin        


Download         Length: 313 a.a.        Molecular weight: 35906.66 Da        Isoelectric Point: 9.3197

>T90429 WP_101898596.1 NZ_CP025491:3030283-3031221 [Legionella sainthelensi]
MKRCPITYDVISDQENYSQRGLHLLSPQLKNLSPLDLSADEQRQEAIARVGKMSIQGVQKKLSAKLKIKEGCFEIVDQKG
QYILKPQSDIYPELPENEAITMTLAKTIGLEVPVHGLIYSKDNSFTYFIKRFDRIGHNKKLAVEDFAQLSGEDRHTKYKS
SMEKVIAVIAQFCTFPKIEFVKLFKLTLFNFLVGNEDMHLKNFSLITKERKISISPAYDLLNSTIAQKNTKEELALPLKG
KKNNVTKSDFLKYFAIEKLGLNQNVIDGIVQEFHQVIPKWQELIGSSFLSQSMQEKYLELLEQRCKRLNFFD

Download         Length: 939 bp

>T90429 NZ_CP025491:3030283-3031221 [Legionella sainthelensi]
ATGAAACGCTGCCCTATTACTTATGACGTAATTAGTGACCAAGAAAACTATTCACAACGTGGATTGCATTTGCTGTCTCC
TCAATTAAAAAACCTTAGTCCATTAGATTTAAGTGCTGATGAGCAGCGACAGGAAGCAATTGCTCGGGTAGGAAAGATGT
CTATTCAGGGCGTCCAAAAAAAACTAAGTGCCAAATTAAAGATTAAAGAGGGATGTTTTGAAATCGTTGATCAAAAGGGT
CAGTATATTTTAAAACCACAAAGTGATATTTATCCAGAATTACCTGAAAATGAAGCCATTACTATGACCCTTGCAAAGAC
CATTGGCCTCGAAGTTCCGGTTCATGGTTTGATTTATTCTAAAGACAACAGTTTCACCTACTTCATTAAACGCTTTGATC
GAATAGGCCATAATAAAAAGTTAGCTGTAGAAGATTTTGCACAGCTATCAGGTGAAGATCGACATACAAAATATAAAAGT
TCTATGGAAAAAGTAATTGCAGTCATAGCACAGTTTTGTACATTCCCAAAAATTGAATTCGTGAAATTATTTAAGTTGAC
GTTGTTTAACTTCCTGGTCGGCAATGAAGACATGCATCTAAAAAATTTTTCCCTGATTACTAAGGAAAGAAAAATTTCCA
TATCACCAGCCTACGATTTACTTAACTCAACCATCGCTCAAAAAAATACCAAAGAAGAACTGGCTTTACCTCTAAAAGGA
AAAAAAAATAATGTAACAAAGAGCGATTTTCTTAAATATTTTGCCATTGAAAAATTAGGATTAAACCAGAACGTCATCGA
TGGGATCGTACAAGAGTTTCATCAGGTAATACCAAAATGGCAAGAGCTGATTGGTTCCAGTTTTTTATCTCAGTCGATGC
AGGAAAAATATCTCGAATTGCTAGAGCAACGGTGCAAGCGATTAAATTTTTTTGATTAA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11598.48 Da        Isoelectric Point: 4.6017

>AT90429 WP_101898595.1 NZ_CP025491:3029978-3030286 [Legionella sainthelensi]
MRKAYVSVNGIKAGVLEELEGKKYQFTYLNDYQGAPVSLTMPLTNKIYDFDVFPPFFEGLLPEGIMLEALLRKYKIDKND
YFGQLILVGQDVVGAVTIEELR

Download         Length: 309 bp

>AT90429 NZ_CP025491:3029978-3030286 [Legionella sainthelensi]
ATGAGAAAAGCATACGTATCAGTGAATGGCATTAAAGCTGGAGTATTAGAAGAATTAGAAGGTAAAAAATATCAATTTAC
TTACCTTAATGATTATCAGGGGGCACCTGTTTCTCTCACCATGCCGTTAACCAATAAGATCTATGATTTTGACGTATTTC
CTCCTTTTTTTGAAGGGTTGCTACCTGAAGGTATTATGCTTGAAGCATTATTACGCAAATATAAAATCGATAAAAATGAT
TATTTTGGTCAATTGATACTAGTTGGCCAAGATGTCGTAGGTGCAGTGACTATTGAGGAACTAAGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References