Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | HipBST/HipA(toxin) |
Location | 3029978..3031221 | Replicon | chromosome |
Accession | NZ_CP025491 | ||
Organism | Legionella sainthelensi strain LA01-117 |
Toxin (Protein)
Gene name | HipT | Uniprot ID | - |
Locus tag | CAB17_RS13365 | Protein ID | WP_101898596.1 |
Coordinates | 3030283..3031221 (+) | Length | 313 a.a. |
Antitoxin (Protein)
Gene name | HipS | Uniprot ID | - |
Locus tag | CAB17_RS13360 | Protein ID | WP_101898595.1 |
Coordinates | 3029978..3030286 (+) | Length | 103 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
CAB17_RS13335 | 3025418..3025645 | + | 228 | WP_101898590.1 | helix-turn-helix transcriptional regulator | - |
CAB17_RS13340 | 3025632..3026852 | + | 1221 | WP_101898591.1 | type II toxin-antitoxin system HipA family toxin | - |
CAB17_RS13345 | 3027110..3028621 | + | 1512 | WP_101898592.1 | Fic family protein | - |
CAB17_RS13350 | 3028658..3029365 | + | 708 | WP_101898593.1 | hypothetical protein | - |
CAB17_RS13355 | 3029754..3029981 | + | 228 | WP_101898594.1 | helix-turn-helix transcriptional regulator | - |
CAB17_RS13360 | 3029978..3030286 | + | 309 | WP_101898595.1 | HipA N-terminal domain-containing protein | Antitoxin |
CAB17_RS13365 | 3030283..3031221 | + | 939 | WP_101898596.1 | lpg2370 family Dot/Icm T4SS effector | Toxin |
CAB17_RS13370 | 3031310..3031495 | - | 186 | Protein_2612 | integrase | - |
CAB17_RS13375 | 3031917..3033647 | + | 1731 | WP_101898597.1 | hypothetical protein | - |
CAB17_RS13380 | 3033914..3035284 | - | 1371 | WP_129556899.1 | MFS transporter | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 313 a.a. Molecular weight: 35906.66 Da Isoelectric Point: 9.3197
>T90429 WP_101898596.1 NZ_CP025491:3030283-3031221 [Legionella sainthelensi]
MKRCPITYDVISDQENYSQRGLHLLSPQLKNLSPLDLSADEQRQEAIARVGKMSIQGVQKKLSAKLKIKEGCFEIVDQKG
QYILKPQSDIYPELPENEAITMTLAKTIGLEVPVHGLIYSKDNSFTYFIKRFDRIGHNKKLAVEDFAQLSGEDRHTKYKS
SMEKVIAVIAQFCTFPKIEFVKLFKLTLFNFLVGNEDMHLKNFSLITKERKISISPAYDLLNSTIAQKNTKEELALPLKG
KKNNVTKSDFLKYFAIEKLGLNQNVIDGIVQEFHQVIPKWQELIGSSFLSQSMQEKYLELLEQRCKRLNFFD
MKRCPITYDVISDQENYSQRGLHLLSPQLKNLSPLDLSADEQRQEAIARVGKMSIQGVQKKLSAKLKIKEGCFEIVDQKG
QYILKPQSDIYPELPENEAITMTLAKTIGLEVPVHGLIYSKDNSFTYFIKRFDRIGHNKKLAVEDFAQLSGEDRHTKYKS
SMEKVIAVIAQFCTFPKIEFVKLFKLTLFNFLVGNEDMHLKNFSLITKERKISISPAYDLLNSTIAQKNTKEELALPLKG
KKNNVTKSDFLKYFAIEKLGLNQNVIDGIVQEFHQVIPKWQELIGSSFLSQSMQEKYLELLEQRCKRLNFFD
Download Length: 939 bp
>T90429 NZ_CP025491:3030283-3031221 [Legionella sainthelensi]
ATGAAACGCTGCCCTATTACTTATGACGTAATTAGTGACCAAGAAAACTATTCACAACGTGGATTGCATTTGCTGTCTCC
TCAATTAAAAAACCTTAGTCCATTAGATTTAAGTGCTGATGAGCAGCGACAGGAAGCAATTGCTCGGGTAGGAAAGATGT
CTATTCAGGGCGTCCAAAAAAAACTAAGTGCCAAATTAAAGATTAAAGAGGGATGTTTTGAAATCGTTGATCAAAAGGGT
CAGTATATTTTAAAACCACAAAGTGATATTTATCCAGAATTACCTGAAAATGAAGCCATTACTATGACCCTTGCAAAGAC
CATTGGCCTCGAAGTTCCGGTTCATGGTTTGATTTATTCTAAAGACAACAGTTTCACCTACTTCATTAAACGCTTTGATC
GAATAGGCCATAATAAAAAGTTAGCTGTAGAAGATTTTGCACAGCTATCAGGTGAAGATCGACATACAAAATATAAAAGT
TCTATGGAAAAAGTAATTGCAGTCATAGCACAGTTTTGTACATTCCCAAAAATTGAATTCGTGAAATTATTTAAGTTGAC
GTTGTTTAACTTCCTGGTCGGCAATGAAGACATGCATCTAAAAAATTTTTCCCTGATTACTAAGGAAAGAAAAATTTCCA
TATCACCAGCCTACGATTTACTTAACTCAACCATCGCTCAAAAAAATACCAAAGAAGAACTGGCTTTACCTCTAAAAGGA
AAAAAAAATAATGTAACAAAGAGCGATTTTCTTAAATATTTTGCCATTGAAAAATTAGGATTAAACCAGAACGTCATCGA
TGGGATCGTACAAGAGTTTCATCAGGTAATACCAAAATGGCAAGAGCTGATTGGTTCCAGTTTTTTATCTCAGTCGATGC
AGGAAAAATATCTCGAATTGCTAGAGCAACGGTGCAAGCGATTAAATTTTTTTGATTAA
ATGAAACGCTGCCCTATTACTTATGACGTAATTAGTGACCAAGAAAACTATTCACAACGTGGATTGCATTTGCTGTCTCC
TCAATTAAAAAACCTTAGTCCATTAGATTTAAGTGCTGATGAGCAGCGACAGGAAGCAATTGCTCGGGTAGGAAAGATGT
CTATTCAGGGCGTCCAAAAAAAACTAAGTGCCAAATTAAAGATTAAAGAGGGATGTTTTGAAATCGTTGATCAAAAGGGT
CAGTATATTTTAAAACCACAAAGTGATATTTATCCAGAATTACCTGAAAATGAAGCCATTACTATGACCCTTGCAAAGAC
CATTGGCCTCGAAGTTCCGGTTCATGGTTTGATTTATTCTAAAGACAACAGTTTCACCTACTTCATTAAACGCTTTGATC
GAATAGGCCATAATAAAAAGTTAGCTGTAGAAGATTTTGCACAGCTATCAGGTGAAGATCGACATACAAAATATAAAAGT
TCTATGGAAAAAGTAATTGCAGTCATAGCACAGTTTTGTACATTCCCAAAAATTGAATTCGTGAAATTATTTAAGTTGAC
GTTGTTTAACTTCCTGGTCGGCAATGAAGACATGCATCTAAAAAATTTTTCCCTGATTACTAAGGAAAGAAAAATTTCCA
TATCACCAGCCTACGATTTACTTAACTCAACCATCGCTCAAAAAAATACCAAAGAAGAACTGGCTTTACCTCTAAAAGGA
AAAAAAAATAATGTAACAAAGAGCGATTTTCTTAAATATTTTGCCATTGAAAAATTAGGATTAAACCAGAACGTCATCGA
TGGGATCGTACAAGAGTTTCATCAGGTAATACCAAAATGGCAAGAGCTGATTGGTTCCAGTTTTTTATCTCAGTCGATGC
AGGAAAAATATCTCGAATTGCTAGAGCAACGGTGCAAGCGATTAAATTTTTTTGATTAA
Antitoxin
Download Length: 103 a.a. Molecular weight: 11598.48 Da Isoelectric Point: 4.6017
>AT90429 WP_101898595.1 NZ_CP025491:3029978-3030286 [Legionella sainthelensi]
MRKAYVSVNGIKAGVLEELEGKKYQFTYLNDYQGAPVSLTMPLTNKIYDFDVFPPFFEGLLPEGIMLEALLRKYKIDKND
YFGQLILVGQDVVGAVTIEELR
MRKAYVSVNGIKAGVLEELEGKKYQFTYLNDYQGAPVSLTMPLTNKIYDFDVFPPFFEGLLPEGIMLEALLRKYKIDKND
YFGQLILVGQDVVGAVTIEELR
Download Length: 309 bp
>AT90429 NZ_CP025491:3029978-3030286 [Legionella sainthelensi]
ATGAGAAAAGCATACGTATCAGTGAATGGCATTAAAGCTGGAGTATTAGAAGAATTAGAAGGTAAAAAATATCAATTTAC
TTACCTTAATGATTATCAGGGGGCACCTGTTTCTCTCACCATGCCGTTAACCAATAAGATCTATGATTTTGACGTATTTC
CTCCTTTTTTTGAAGGGTTGCTACCTGAAGGTATTATGCTTGAAGCATTATTACGCAAATATAAAATCGATAAAAATGAT
TATTTTGGTCAATTGATACTAGTTGGCCAAGATGTCGTAGGTGCAGTGACTATTGAGGAACTAAGATGA
ATGAGAAAAGCATACGTATCAGTGAATGGCATTAAAGCTGGAGTATTAGAAGAATTAGAAGGTAAAAAATATCAATTTAC
TTACCTTAATGATTATCAGGGGGCACCTGTTTCTCTCACCATGCCGTTAACCAATAAGATCTATGATTTTGACGTATTTC
CTCCTTTTTTTGAAGGGTTGCTACCTGAAGGTATTATGCTTGAAGCATTATTACGCAAATATAAAATCGATAAAAATGAT
TATTTTGGTCAATTGATACTAGTTGGCCAAGATGTCGTAGGTGCAGTGACTATTGAGGAACTAAGATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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