Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 2791999..2792603 Replicon chromosome
Accession NZ_CP025491
Organism Legionella sainthelensi strain LA01-117

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag CAB17_RS12235 Protein ID WP_101898434.1
Coordinates 2792292..2792603 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag CAB17_RS12230 Protein ID WP_101898433.1
Coordinates 2791999..2792289 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CAB17_RS12205 2787307..2787876 + 570 WP_027272054.1 aminoacyl-tRNA hydrolase -
CAB17_RS12210 2787933..2789024 + 1092 WP_027272055.1 redox-regulated ATPase YchF -
CAB17_RS12215 2789103..2790071 + 969 WP_101898431.1 polyprenyl synthetase family protein -
CAB17_RS12225 2791056..2791835 + 780 WP_101898432.1 DUF4111 domain-containing protein -
CAB17_RS12230 2791999..2792289 - 291 WP_101898433.1 helix-turn-helix domain-containing protein Antitoxin
CAB17_RS12235 2792292..2792603 - 312 WP_101898434.1 hypothetical protein Toxin
CAB17_RS12240 2792826..2793395 + 570 WP_101898435.1 recombinase family protein -
CAB17_RS12245 2793980..2794843 + 864 WP_101898436.1 nucleotidyltransferase -
CAB17_RS12250 2794836..2795654 + 819 WP_101898437.1 DUF1624 domain-containing protein -
CAB17_RS12255 2796006..2796323 + 318 WP_101898438.1 YbjQ family protein -
CAB17_RS12260 2796414..2797535 - 1122 WP_101898439.1 alkene reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(37-88)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11954.73 Da        Isoelectric Point: 8.3333

>T90427 WP_101898434.1 NZ_CP025491:c2792603-2792292 [Legionella sainthelensi]
MIFIETPIFTEDVKELLSDDEYAEFQEYLAANPLAGDVIQQTGGLRKVRWSSQGKGKRGGVRIIYYYVNPASQIRLLLIY
KKGIQDDLTADQKKMLRQLNERW

Download         Length: 312 bp

>T90427 NZ_CP025491:c2792603-2792292 [Legionella sainthelensi]
ATGATTTTTATTGAAACTCCAATTTTCACAGAAGACGTAAAAGAATTATTATCTGATGACGAGTATGCTGAGTTTCAAGA
GTATCTTGCTGCTAATCCTTTAGCTGGAGATGTAATCCAGCAAACTGGCGGACTACGAAAAGTTCGGTGGTCATCTCAAG
GTAAGGGGAAGCGAGGTGGTGTTAGAATTATTTATTATTATGTAAATCCTGCTTCACAAATAAGACTCTTACTTATTTAT
AAGAAAGGTATTCAAGATGATCTGACTGCAGATCAAAAGAAAATGTTACGGCAATTAAATGAACGGTGGTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 11014.70 Da        Isoelectric Point: 8.0670

>AT90427 WP_101898433.1 NZ_CP025491:c2792289-2791999 [Legionella sainthelensi]
MDKKLFERLYESMTQMNEIIDGERAPSREFIVDAVHVKEIRKKTGLTQEKFCHLIDVNIGTLRNWEQGRREPTGPAKALL
RAINKDPEHVLAALAS

Download         Length: 291 bp

>AT90427 NZ_CP025491:c2792289-2791999 [Legionella sainthelensi]
ATGGATAAAAAATTGTTTGAACGACTATATGAAAGTATGACTCAGATGAATGAAATTATTGATGGTGAGCGCGCTCCTTC
ACGCGAGTTCATAGTAGATGCTGTTCATGTAAAAGAAATTAGAAAAAAAACAGGCCTAACCCAAGAAAAATTTTGTCATT
TAATTGATGTAAATATTGGAACGTTAAGAAATTGGGAGCAGGGGAGGAGAGAGCCAACAGGTCCCGCAAAAGCCCTTCTT
CGCGCCATAAATAAAGATCCTGAACATGTATTAGCAGCATTAGCTAGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References