Detailed information of TA system TA090422

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 2571719..2572374
• Replicon: chromosome
• Accession: NZ_CP025479
• Organism: Bordetella pertussis strain I892

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: CYG30_RS12460
• Protein ID: WP_047122780.1
• Coordinates: 2572123..2572374 (-)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: Q7VY40
• Locus tag: CYG30_RS12455
• Protein ID: WP_003809516.1
• Coordinates: 2571719..2572120 (-)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CYG30_RS12425	2566902..2567924	-	1023	WP_003809532.1	amino acid ABC transporter substrate-binding protein	-
CYG30_RS12430	2568061..2569098	-	1038	WP_023853543.1	threonylcarbamoyl-AMP synthase	-
CYG30_RS12435	2569118..2570308	-	1191	WP_010930406.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
CYG30_RS12440	2570311..2570826	-	516	WP_019247930.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
CYG30_RS12445	2570976..2571455	-	480	WP_010930405.1	disulfide bond formation protein B	-
CYG30_RS12450	2571463..2571699	-	237	WP_010930404.1	membrane protein	-
CYG30_RS12455	2571719..2572120	-	402	WP_003809516.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
CYG30_RS12460	2572123..2572374	-	252	WP_047122780.1	type II toxin-antitoxin system MqsR family toxin	Toxin
CYG30_RS12465	2572429..2573310	-	882	WP_003809513.1	phosphoribosylaminoimidazolesuccinocarboxamide synthase	-
CYG30_RS12470	2573535..2573981	+	447	WP_003819827.1	GFA family protein	-
CYG30_RS12475	2574066..2575130	-	1065	WP_003809510.1	fructose-bisphosphate aldolase class II	-
CYG30_RS12480	2575267..2575848	-	582	WP_019247931.1	molybdenum cofactor biosysynthesis protein	-
CYG30_RS12485	2576083..2577213	+	1131	WP_010930401.1	helix-turn-helix transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (10-82)

Antitoxin

• Antitoxin MqsA/HigA-2 (1-131)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 8952.52 Da
• Isoelectric Point: 9.7242

>T90422 WP_047122780.1 NZ_CP025479:c2572374-2572123 [Bordetella pertussis]
IGGAATKKPGQKRRAGAAALGLDFSAMVEIVLALTPRDFHKSMTTHADHRIWQDVYCPVTAMGAVYLKLTVLDGVPIVSF
KEL

Nucleotide

• Length: 252 bp

>T90422 NZ_CP025479:c2572374-2572123 [Bordetella pertussis]
ATTGGAGGCGCGGCGACAAAAAAGCCGGGACAAAAGCGTCGCGCCGGGGCGGCGGCGCTGGGGCTGGATTTCAGCGCCAT
GGTCGAAATCGTGCTTGCATTGACACCGCGGGATTTCCACAAAAGCATGACTACCCATGCCGACCATCGCATTTGGCAGG
ACGTCTATTGCCCGGTGACAGCGATGGGCGCCGTCTACCTGAAGCTGACGGTCCTCGACGGCGTGCCGATCGTGTCGTTC
AAGGAGTTGTGA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14528.70 Da
• Isoelectric Point: 8.5005

>AT90422 WP_003809516.1 NZ_CP025479:c2572120-2571719 [Bordetella pertussis]
MKCPVCGAAALARDTRDVPYSYKGETITIAAVTGDWCPACGENVLDGAESARVSEAMLAFNRLVNARRVDPGFIVRVRRK
LGLDQREAAALFGGGTNAFSRYENGKTRPPLALVKLLRLLDRHPELLEEVRAD

Nucleotide

• Length: 402 bp

>AT90422 NZ_CP025479:c2572120-2571719 [Bordetella pertussis]
ATGAAGTGTCCCGTATGCGGAGCGGCCGCGCTGGCGCGTGATACTCGCGATGTGCCCTATAGCTACAAGGGCGAGACCAT
CACGATTGCGGCGGTGACGGGCGACTGGTGTCCGGCATGCGGCGAGAACGTGCTCGATGGCGCTGAATCGGCGCGGGTGA
GCGAGGCCATGCTGGCTTTCAACCGCCTGGTCAACGCCCGCCGCGTCGACCCCGGGTTCATCGTGCGGGTGCGCAGGAAG
CTGGGGCTGGACCAGCGCGAAGCCGCGGCGCTGTTCGGCGGCGGCACCAATGCGTTCTCGCGTTACGAGAACGGCAAGAC
GCGCCCGCCGCTGGCGCTGGTGAAGCTGCTCAGGCTGCTGGATCGCCATCCGGAGCTGCTGGAGGAAGTCCGTGCGGATT
GA

Structures

Antitoxin

• AlphaFold DB: A0A0H3LKS6