Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 92021..92291 Replicon plasmid p69-2
Accession NZ_CP025458
Organism Klebsiella pneumoniae strain KP69

Toxin (Protein)


Gene name hok Uniprot ID P11895
Locus tag CYD98_RS30590 Protein ID WP_001312861.1
Coordinates 92133..92291 (+) Length 53 a.a.

Antitoxin (RNA)


Gene name sok
Locus tag -
Coordinates 92021..92084 (-)

Genomic Context

CYD98_RS29970CYD98_RS29975CYD98_RS29980CYD98_RS29985CYD98_RS29990----CYD98_RS30590CYD98_RS30015CYD98_RS30020CYD98_RS30030CYD98_RS30035CYD98_RS30040--CYD98_RS31240CYD98_RS30025
Location: 87732..88259 (528 bp)
Type: Others
Protein ID: WP_000290834.1
Location: 88317..88550 (234 bp)
Type: Others
Protein ID: WP_000006003.1
Location: 88611..90634 (2024 bp)
Type: Others
Protein ID: Protein_120
Location: 90703..91137 (435 bp)
Type: Others
Protein ID: WP_000845953.1
Location: 91134..91853 (720 bp)
Type: Others
Protein ID: WP_001276217.1
Location: 91865..92089 (225 bp)
Type: Others
Protein ID: NuclAT_0
Location: 91865..92089 (225 bp)
Type: Others
Protein ID: NuclAT_0
Location: 91865..92089 (225 bp)
Type: Others
Protein ID: NuclAT_0
Location: 91865..92089 (225 bp)
Type: Others
Protein ID: NuclAT_0
Location: 92133..92291 (159 bp)
Type: Toxin
Protein ID: WP_001312861.1
Location: 93206..93502 (297 bp)
Type: Others
Protein ID: WP_001272251.1
Location: 93613..94434 (822 bp)
Type: Others
Protein ID: WP_001234445.1
Location: 95655..96038 (384 bp)
Type: Others
Protein ID: WP_000124981.1
Location: 96229..96915 (687 bp)
Type: Others
Protein ID: WP_015059009.1
Location: 97009..97236 (228 bp)
Type: Others
Protein ID: WP_001254386.1
Location: 92021..92084 (64 bp)
Type: Antitoxin
Protein ID: -
Location: 92529..92906 (378 bp)
Type: Others
Protein ID: Protein_124
Location: 94731..95378 (648 bp)
Type: Others
Protein ID: WP_015059008.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
CYD98_RS2997087732..88259+528WP_000290834.1single-stranded DNA-binding protein-
CYD98_RS2997588317..88550+234WP_000006003.1DUF905 family protein-
CYD98_RS2998088611..90634+2024Protein_120ParB/RepB/Spo0J family partition protein-
CYD98_RS2998590703..91137+435WP_000845953.1conjugation system SOS inhibitor PsiB-
CYD98_RS2999091134..91853+720WP_001276217.1plasmid SOS inhibition protein A-
-91865..92089+225NuclAT_0--
-91865..92089+225NuclAT_0--
-91865..92089+225NuclAT_0--
-91865..92089+225NuclAT_0--
-92021..92084-64--Antitoxin
CYD98_RS3059092133..92291+159WP_001312861.1type I toxin-antitoxin system Hok family toxinToxin
CYD98_RS3124092529..92906-378Protein_124hypothetical protein-
CYD98_RS3001593206..93502+297WP_001272251.1hypothetical protein-
CYD98_RS3002093613..94434+822WP_001234445.1DUF945 domain-containing protein-
CYD98_RS3002594731..95378-648WP_015059008.1transglycosylase SLT domain-containing protein-
CYD98_RS3003095655..96038+384WP_000124981.1relaxosome protein TraM-
CYD98_RS3003596229..96915+687WP_015059009.1PAS domain-containing protein-
CYD98_RS3004097009..97236+228WP_001254386.1conjugal transfer relaxosome protein TraY-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideMobilizable plasmidcatA2 / blaCTX-M-65 / blaTEM-1B / rmtB / blaSHV-12 / blaKPC-2-1..128563128563


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(8-48)


Sequences

Toxin        


Download         Length: 53 a.a.        Molecular weight: 6082.32 Da        Isoelectric Point: 9.2584

>T90358 WP_001312861.1 NZ_CP025458:92133-92291 [Klebsiella pneumoniae]
MKLPRSSLVWCVLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK

Download         Length: 159 bp

>T90358 NZ_CP025458:92133-92291 [Klebsiella pneumoniae]
ATGAAACTACCACGAAGTTCCCTTGTCTGGTGTGTGTTGATCGTGTGTCTCACACTGTTGATATTCACTTATCTGACACG
AAAATCGCTGTGCGAGATTCGTTACAGAGACGGACACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG

Antitoxin


Download         Length: 64 bp

>AT90358 NZ_CP025458:c92084-92021 [Klebsiella pneumoniae]
GACTAGACATAGGGATGCCTCGTGGTGGTTAATGAAAATTAACTTACTACGGGGCTATCTTCTT

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBP11895

Antitoxin

Download structure file

References