Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 2074906..2075425 Replicon chromosome
Accession NZ_CP025419
Organism Streptococcus suis strain SH0104

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0K2E7Z7
Locus tag CRH08_RS10665 Protein ID WP_013730620.1
Coordinates 2074906..2075163 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0K2E7Z9
Locus tag CRH08_RS10670 Protein ID WP_002939010.1
Coordinates 2075165..2075425 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CRH08_RS10650 2071377..2073107 - 1731 WP_009910905.1 membrane protein -
CRH08_RS10655 2073470..2074378 - 909 WP_074411269.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
CRH08_RS10660 2074362..2074892 - 531 WP_009910909.1 DUF1697 domain-containing protein -
CRH08_RS10665 2074906..2075163 - 258 WP_013730620.1 Txe/YoeB family addiction module toxin Toxin
CRH08_RS10670 2075165..2075425 - 261 WP_002939010.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CRH08_RS10675 2075501..2075956 - 456 WP_013730621.1 8-oxo-dGTP diphosphatase -
CRH08_RS10680 2075960..2076328 - 369 WP_013730622.1 hypothetical protein -
CRH08_RS10685 2076321..2076890 - 570 WP_022540720.1 ribonuclease M5 -
CRH08_RS10690 2076874..2077656 - 783 WP_002939015.1 TatD family hydrolase -
CRH08_RS10695 2077764..2077901 - 138 WP_002939016.1 50S ribosomal protein L34 -
CRH08_RS10700 2078069..2079064 - 996 WP_013730624.1 protein jag -
CRH08_RS10705 2079084..2079896 - 813 WP_004194552.1 YidC/Oxa1 family membrane protein insertase -
CRH08_RS10710 2079880..2080239 - 360 WP_013730625.1 ribonuclease P protein component -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10346.86 Da        Isoelectric Point: 8.0279

>T90318 WP_013730620.1 NZ_CP025419:c2075163-2074906 [Streptococcus suis]
MGIHFTDDAWEDYLYWQGQDKKTLKRINKIIKDMQRHPFEGIAKPEPLKYDYQGAWSRRIDAENRLIYMVEADRLCILSL
KDHYR

Download         Length: 258 bp

>T90318 NZ_CP025419:c2075163-2074906 [Streptococcus suis]
ATGGGAATCCATTTTACAGACGACGCCTGGGAAGACTATCTTTATTGGCAGGGTCAGGATAAGAAAACACTGAAGAGAAT
CAATAAGATTATCAAGGATATGCAGCGACATCCTTTTGAAGGCATTGCCAAACCAGAACCTTTGAAGTATGATTATCAAG
GTGCCTGGTCTCGGAGAATTGATGCGGAGAATCGGTTGATTTATATGGTGGAAGCTGATCGGTTGTGCATCCTGTCGCTA
AAGGATCATTATAGGTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9980.36 Da        Isoelectric Point: 5.7134

>AT90318 WP_002939010.1 NZ_CP025419:c2075425-2075165 [Streptococcus suis]
MEAIVYSHFRNHLKDYMKKVNDEFEPLVVVNKNPEEDIVVLSKSEWDSLQETLAVARNTYLSQKVLRGMAKVKTGQTQER
NLIEAD

Download         Length: 261 bp

>AT90318 NZ_CP025419:c2075425-2075165 [Streptococcus suis]
ATGGAAGCTATTGTATATTCCCATTTTCGAAATCACTTAAAGGACTATATGAAAAAGGTCAATGACGAGTTTGAACCTTT
GGTCGTGGTTAATAAAAATCCAGAGGAAGATATTGTTGTACTCTCAAAGAGTGAGTGGGATAGTTTACAAGAAACCCTCG
CTGTTGCTCGGAACACTTATCTGTCTCAAAAAGTCCTACGTGGTATGGCTAAAGTCAAAACGGGACAAACCCAAGAACGA
AACCTGATAGAGGCGGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K2E7Z7

Antitoxin

Source ID Structure
AlphaFold DB A0A0K2E7Z9

References