Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2483607..2483791 Replicon chromosome
Accession NZ_CP025395
Organism Staphylococcus aureus O46

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2P7CQJ7
Locus tag SAO46_RS12800 Protein ID WP_000482647.1
Coordinates 2483684..2483791 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2483607..2483667 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAO46_RS12775 2479061..2479228 - 168 WP_031901225.1 hypothetical protein -
SAO46_RS12785 2479459..2481192 - 1734 WP_000486494.1 ABC transporter ATP-binding protein/permease -
SAO46_RS12790 2481217..2482980 - 1764 WP_001064823.1 ABC transporter ATP-binding protein/permease -
- 2483607..2483667 + 61 - - Antitoxin
SAO46_RS12800 2483684..2483791 - 108 WP_000482647.1 type I toxin-antitoxin system Fst family toxin Toxin
SAO46_RS12805 2483925..2484311 - 387 WP_000779350.1 flippase GtxA -
SAO46_RS12810 2484579..2485721 + 1143 WP_001176867.1 glycerate kinase -
SAO46_RS12815 2485781..2486440 + 660 WP_000831298.1 membrane protein -
SAO46_RS12820 2486623..2487834 + 1212 WP_001191929.1 multidrug effflux MFS transporter -
SAO46_RS12825 2487957..2488430 - 474 WP_000456488.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4012.76 Da        Isoelectric Point: 10.4935

>T90259 WP_000482647.1 NZ_CP025395:c2483791-2483684 [Staphylococcus aureus O46]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T90259 NZ_CP025395:c2483791-2483684 [Staphylococcus aureus O46]
ATGTTCAATTTATTAATTGACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT90259 NZ_CP025395:2483607-2483667 [Staphylococcus aureus O46]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P7CQJ7

Antitoxin

Download structure file

References