Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2458303..2458820 Replicon chromosome
Accession NZ_CP025395
Organism Staphylococcus aureus O46

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag SAO46_RS12645 Protein ID WP_000113259.1
Coordinates 2458303..2458569 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag SAO46_RS12650 Protein ID WP_000584500.1
Coordinates 2458569..2458820 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAO46_RS12620 2453473..2454009 - 537 WP_000185899.1 GNAT family N-acetyltransferase -
SAO46_RS12625 2454509..2455333 - 825 WP_000594633.1 formate/nitrite transporter family protein -
SAO46_RS12630 2455536..2455718 - 183 WP_000079140.1 hypothetical protein -
SAO46_RS12635 2455805..2456272 - 468 WP_000153340.1 SRPBCC domain-containing protein -
SAO46_RS12640 2456458..2458008 - 1551 WP_000727763.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
SAO46_RS12645 2458303..2458569 - 267 WP_000113259.1 Txe/YoeB family addiction module toxin Toxin
SAO46_RS12650 2458569..2458820 - 252 WP_000584500.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
SAO46_RS12655 2458984..2459082 - 99 Protein_2355 hypothetical protein -
SAO46_RS12660 2459092..2459691 - 600 WP_000162810.1 DsbA family protein -
SAO46_RS12665 2459710..2460072 - 363 WP_000819848.1 DUF4467 domain-containing protein -
SAO46_RS12670 2460328..2461578 + 1251 WP_001012232.1 FemA/FemB family glycyltransferase FmhA -
SAO46_RS12675 2461675..2462406 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
SAO46_RS12680 2462403..2463122 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10464.08 Da        Isoelectric Point: 10.2538

>T90258 WP_000113259.1 NZ_CP025395:c2458569-2458303 [Staphylococcus aureus O46]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELIKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYKVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T90258 NZ_CP025395:c2458569-2458303 [Staphylococcus aureus O46]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTAATTAAAAGTATTGACAGAAATGGTGCATTGAAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATAAAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9419.58 Da        Isoelectric Point: 4.3407

>AT90258 WP_000584500.1 NZ_CP025395:c2458820-2458569 [Staphylococcus aureus O46]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTVTKD
IDV

Download         Length: 252 bp

>AT90258 NZ_CP025395:c2458820-2458569 [Staphylococcus aureus O46]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACCTCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTGTAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References