Detailed information of TA system TA090224

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 1494892..1495547
• Replicon: chromosome
• Accession: NZ_CP025377
• Organism: Bordetella pertussis strain I323

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: CX037_RS07345
• Protein ID: WP_047122780.1
• Coordinates: 1494892..1495143 (+)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: Q7VY40
• Locus tag: CX037_RS07350
• Protein ID: WP_003809516.1
• Coordinates: 1495146..1495547 (+)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CX037_RS07320	1490053..1491183	-	1131	WP_010930401.1	helix-turn-helix transcriptional regulator	-
CX037_RS07325	1491418..1491999	+	582	WP_019247931.1	molybdenum cofactor biosysynthesis protein	-
CX037_RS07330	1492136..1493200	+	1065	WP_003809510.1	fructose-bisphosphate aldolase class II	-
CX037_RS07335	1493285..1493731	-	447	WP_003819827.1	GFA family protein	-
CX037_RS07340	1493956..1494837	+	882	WP_003809513.1	phosphoribosylaminoimidazolesuccinocarboxamide synthase	-
CX037_RS07345	1494892..1495143	+	252	WP_047122780.1	type II toxin-antitoxin system MqsR family toxin	Toxin
CX037_RS07350	1495146..1495547	+	402	WP_003809516.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
CX037_RS07355	1495567..1495803	+	237	WP_010930404.1	membrane protein	-
CX037_RS07360	1495811..1496290	+	480	WP_010930405.1	disulfide bond formation protein B	-
CX037_RS07365	1496440..1496955	+	516	WP_019247930.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
CX037_RS07370	1496958..1498148	+	1191	WP_010930406.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
CX037_RS07375	1498168..1499205	+	1038	WP_023853543.1	threonylcarbamoyl-AMP synthase	-
CX037_RS07380	1499342..1500364	+	1023	WP_003809532.1	amino acid ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (10-82)

Antitoxin

• Antitoxin MqsA/HigA-2 (1-131)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 8952.52 Da
• Isoelectric Point: 9.7242

>T90224 WP_047122780.1 NZ_CP025377:1494892-1495143 [Bordetella pertussis]
IGGAATKKPGQKRRAGAAALGLDFSAMVEIVLALTPRDFHKSMTTHADHRIWQDVYCPVTAMGAVYLKLTVLDGVPIVSF
KEL

Nucleotide

• Length: 252 bp

>T90224 NZ_CP025377:1494892-1495143 [Bordetella pertussis]
ATTGGAGGCGCGGCGACAAAAAAGCCGGGACAAAAGCGTCGCGCCGGGGCGGCGGCGCTGGGGCTGGATTTCAGCGCCAT
GGTCGAAATCGTGCTTGCATTGACACCGCGGGATTTCCACAAAAGCATGACTACCCATGCCGACCATCGCATTTGGCAGG
ACGTCTATTGCCCGGTGACAGCGATGGGCGCCGTCTACCTGAAGCTGACGGTCCTCGACGGCGTGCCGATCGTGTCGTTC
AAGGAGTTGTGA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14528.70 Da
• Isoelectric Point: 8.5005

>AT90224 WP_003809516.1 NZ_CP025377:1495146-1495547 [Bordetella pertussis]
MKCPVCGAAALARDTRDVPYSYKGETITIAAVTGDWCPACGENVLDGAESARVSEAMLAFNRLVNARRVDPGFIVRVRRK
LGLDQREAAALFGGGTNAFSRYENGKTRPPLALVKLLRLLDRHPELLEEVRAD

Nucleotide

• Length: 402 bp

>AT90224 NZ_CP025377:1495146-1495547 [Bordetella pertussis]
ATGAAGTGTCCCGTATGCGGAGCGGCCGCGCTGGCGCGTGATACTCGCGATGTGCCCTATAGCTACAAGGGCGAGACCAT
CACGATTGCGGCGGTGACGGGCGACTGGTGTCCGGCATGCGGCGAGAACGTGCTCGATGGCGCTGAATCGGCGCGGGTGA
GCGAGGCCATGCTGGCTTTCAACCGCCTGGTCAACGCCCGCCGCGTCGACCCCGGGTTCATCGTGCGGGTGCGCAGGAAG
CTGGGGCTGGACCAGCGCGAAGCCGCGGCGCTGTTCGGCGGCGGCACCAATGCGTTCTCGCGTTACGAGAACGGCAAGAC
GCGCCCGCCGCTGGCGCTGGTGAAGCTGCTCAGGCTGCTGGATCGCCATCCGGAGCTGCTGGAGGAAGTCCGTGCGGATT
GA

Structures

Antitoxin

• AlphaFold DB: A0A0H3LKS6