Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 1530189..1530844 Replicon chromosome
Accession NZ_CP025369
Organism Bordetella pertussis strain I223

Toxin (Protein)


Gene name mqsR Uniprot ID -
Locus tag CXD98_RS07470 Protein ID WP_047122780.1
Coordinates 1530189..1530440 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID Q7VY40
Locus tag CXD98_RS07475 Protein ID WP_003809516.1
Coordinates 1530443..1530844 (+) Length 134 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CXD98_RS07445 1525350..1526480 - 1131 WP_010930401.1 helix-turn-helix transcriptional regulator -
CXD98_RS07450 1526715..1527296 + 582 WP_019247931.1 molybdenum cofactor biosysynthesis protein -
CXD98_RS07455 1527433..1528497 + 1065 WP_003809510.1 fructose-bisphosphate aldolase class II -
CXD98_RS07460 1528582..1529028 - 447 WP_003819827.1 GFA family protein -
CXD98_RS07465 1529253..1530134 + 882 WP_003809513.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
CXD98_RS07470 1530189..1530440 + 252 WP_047122780.1 type II toxin-antitoxin system MqsR family toxin Toxin
CXD98_RS07475 1530443..1530844 + 402 WP_003809516.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
CXD98_RS07480 1530864..1531100 + 237 WP_010930404.1 membrane protein -
CXD98_RS07485 1531108..1531587 + 480 WP_010930405.1 disulfide bond formation protein B -
CXD98_RS07490 1531737..1532252 + 516 WP_019247930.1 5-(carboxyamino)imidazole ribonucleotide mutase -
CXD98_RS07495 1532255..1533445 + 1191 WP_010930406.1 5-(carboxyamino)imidazole ribonucleotide synthase -
CXD98_RS07500 1533465..1534502 + 1038 WP_023853543.1 threonylcarbamoyl-AMP synthase -
CXD98_RS07505 1534639..1535661 + 1023 WP_003809532.1 amino acid ABC transporter substrate-binding protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(10-82)

Antitoxin

(1-131)


Sequences


Toxin        


Download         Length: 84 a.a.        Molecular weight: 8952.52 Da        Isoelectric Point: 9.7242

>T90208 WP_047122780.1 NZ_CP025369:1530189-1530440 [Bordetella pertussis]
IGGAATKKPGQKRRAGAAALGLDFSAMVEIVLALTPRDFHKSMTTHADHRIWQDVYCPVTAMGAVYLKLTVLDGVPIVSF
KEL

Download         Length: 252 bp

>T90208 NZ_CP025369:1530189-1530440 [Bordetella pertussis]
ATTGGAGGCGCGGCGACAAAAAAGCCGGGACAAAAGCGTCGCGCCGGGGCGGCGGCGCTGGGGCTGGATTTCAGCGCCAT
GGTCGAAATCGTGCTTGCATTGACACCGCGGGATTTCCACAAAAGCATGACTACCCATGCCGACCATCGCATTTGGCAGG
ACGTCTATTGCCCGGTGACAGCGATGGGCGCCGTCTACCTGAAGCTGACGGTCCTCGACGGCGTGCCGATCGTGTCGTTC
AAGGAGTTGTGA

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14528.70 Da        Isoelectric Point: 8.5005

>AT90208 WP_003809516.1 NZ_CP025369:1530443-1530844 [Bordetella pertussis]
MKCPVCGAAALARDTRDVPYSYKGETITIAAVTGDWCPACGENVLDGAESARVSEAMLAFNRLVNARRVDPGFIVRVRRK
LGLDQREAAALFGGGTNAFSRYENGKTRPPLALVKLLRLLDRHPELLEEVRAD

Download         Length: 402 bp

>AT90208 NZ_CP025369:1530443-1530844 [Bordetella pertussis]
ATGAAGTGTCCCGTATGCGGAGCGGCCGCGCTGGCGCGTGATACTCGCGATGTGCCCTATAGCTACAAGGGCGAGACCAT
CACGATTGCGGCGGTGACGGGCGACTGGTGTCCGGCATGCGGCGAGAACGTGCTCGATGGCGCTGAATCGGCGCGGGTGA
GCGAGGCCATGCTGGCTTTCAACCGCCTGGTCAACGCCCGCCGCGTCGACCCCGGGTTCATCGTGCGGGTGCGCAGGAAG
CTGGGGCTGGACCAGCGCGAAGCCGCGGCGCTGTTCGGCGGCGGCACCAATGCGTTCTCGCGTTACGAGAACGGCAAGAC
GCGCCCGCCGCTGGCGCTGGTGAAGCTGCTCAGGCTGCTGGATCGCCATCCGGAGCTGCTGGAGGAAGTCCGTGCGGATT
GA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A0H3LKS6

References