Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 1826052..1826637 Replicon chromosome
Accession NZ_CP025330
Organism Brevibacterium aurantiacum strain SMQ-1417

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag CXR23_RS08395 Protein ID WP_096162045.1
Coordinates 1826052..1826348 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag CXR23_RS08400 Protein ID WP_096162044.1
Coordinates 1826335..1826637 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CXR23_RS20295 1821180..1821317 - 138 WP_164743329.1 hypothetical protein -
CXR23_RS08375 1821686..1823443 - 1758 WP_096162047.1 oleate hydratase -
CXR23_RS08380 1823531..1824253 + 723 WP_096162046.1 TetR/AcrR family transcriptional regulator -
CXR23_RS08390 1824804..1826079 - 1276 Protein_1654 IS1380 family transposase -
CXR23_RS08395 1826052..1826348 + 297 WP_096162045.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CXR23_RS08400 1826335..1826637 + 303 WP_096162044.1 HigA family addiction module antidote protein Antitoxin
CXR23_RS20430 1826944..1827426 + 483 WP_205676697.1 2-phosphosulfolactate phosphatase -
CXR23_RS08410 1827542..1827931 - 390 WP_096162042.1 VOC family protein -
CXR23_RS08415 1828055..1828420 + 366 WP_069599925.1 alkylphosphonate utilization protein -
CXR23_RS08420 1829557..1829838 + 282 WP_009883719.1 type II toxin-antitoxin system RelE/ParE family toxin -
CXR23_RS08425 1829848..1830147 + 300 WP_009883720.1 HigA family addiction module antidote protein -
CXR23_RS08430 1830181..1831371 + 1191 WP_096146801.1 PD-(D/E)XK nuclease family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1819271..1831371 12100
- flank IS/Tn - - 1824804..1825997 1193


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(10-98)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(5-97)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11423.94 Da        Isoelectric Point: 10.7295

>T90143 WP_096162045.1 NZ_CP025330:1826052-1826348 [Brevibacterium aurantiacum]
MGSLPCPRRFGNNDTERLRRRERVRSIDPRIHRAALRKLRQVGSAESLEDLRVPPGNRLEAPKGDRVGQHSIRINDQWRI
CFVWTDAGPEEVQIVDYH

Download         Length: 297 bp

>T90143 NZ_CP025330:1826052-1826348 [Brevibacterium aurantiacum]
CTGGGTTCGCTCCCTTGTCCGCGCCGGTTCGGCAACAACGACACCGAACGGCTGCGGCGTCGTGAGCGTGTGCGGTCGAT
CGATCCGAGGATTCATCGGGCCGCGCTGCGCAAGCTGCGTCAGGTGGGGTCCGCGGAGTCTCTCGAAGACCTCCGCGTCC
CGCCCGGAAACCGGCTTGAGGCCCCCAAGGGCGATCGGGTCGGACAGCACAGCATCAGGATCAACGACCAGTGGCGGATC
TGCTTCGTGTGGACCGACGCCGGACCGGAGGAGGTGCAGATCGTTGACTACCACTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11005.57 Da        Isoelectric Point: 5.6032

>AT90143 WP_096162044.1 NZ_CP025330:1826335-1826637 [Brevibacterium aurantiacum]
MTTTDRIEPIHLGEVLMEDFIEGFGITQNKLAVSIGVPPRRINEIVHGKRGITGDTALRLAKYFGTSAEFWINLQSHYEL
DRAEDAAGAQIAAITPLRVA

Download         Length: 303 bp

>AT90143 NZ_CP025330:1826335-1826637 [Brevibacterium aurantiacum]
TTGACTACCACTGACAGGATCGAGCCGATCCACCTGGGTGAGGTCCTCATGGAGGACTTCATCGAGGGCTTCGGCATCAC
GCAGAACAAGCTCGCCGTGTCGATCGGAGTGCCGCCTCGGCGGATCAACGAGATTGTGCATGGCAAGCGAGGGATCACAG
GGGACACCGCGCTGCGGCTGGCGAAGTACTTCGGCACCTCGGCCGAGTTCTGGATCAACTTGCAGAGCCACTACGAGCTT
GACCGGGCTGAGGACGCCGCGGGCGCGCAGATCGCGGCGATCACCCCGCTGCGGGTCGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References