Detailed information of TA system TA090075

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symER/SymE(toxin)
• Location: 4670747..4671159
• Replicon: chromosome
• Accession: NZ_CP025317
• Organism: Escherichia albertii strain 1551-2

Toxin (Protein)

• Gene name: symE
• Uniprot ID: A0A8D9PK47
• Locus tag: CXP54_RS23780
• Protein ID: WP_000132619.1
• Coordinates: 4670747..4671088 (-)
• Length: 114 a.a.

Antitoxin (RNA)

Gene name	symR
Locus tag	-
Coordinates	4671083..4671159 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CXP54_RS23760	4665780..4666711	+	932	Protein_4364	Rpn family recombination-promoting nuclease/putative transposase	-
CXP54_RS24310	4666999..4667154	+	156	WP_157944743.1	hypothetical protein	-
CXP54_RS23765	4667376..4668104	+	729	Protein_4366	DUF1998 domain-containing protein	-
CXP54_RS23770	4668160..4669206	-	1047	WP_072252312.1	5-methylcytosine-specific restriction endonuclease system specificity protein McrC	-
CXP54_RS23775	4669206..4670585	-	1380	WP_059217670.1	5-methylcytosine-specific restriction endonuclease subunit McrB	-
CXP54_RS23780	4670747..4671088	-	342	WP_000132619.1	endoribonuclease SymE	Toxin
-	4671083..4671159	+	77	NuclAT_8	-	Antitoxin
-	4671083..4671159	+	77	NuclAT_8	-	Antitoxin
-	4671083..4671159	+	77	NuclAT_8	-	Antitoxin
-	4671083..4671159	+	77	NuclAT_8	-	Antitoxin
-	4671083..4671159	+	77	NuclAT_9	-	Antitoxin
-	4671083..4671159	+	77	NuclAT_9	-	Antitoxin
-	4671083..4671159	+	77	NuclAT_9	-	Antitoxin
-	4671083..4671159	+	77	NuclAT_9	-	Antitoxin
CXP54_RS23785	4671309..4673051	-	1743	WP_103054261.1	restriction endonuclease subunit S	-
CXP54_RS23790	4673051..4674520	-	1470	WP_016159453.1	type I restriction-modification system subunit M	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4666511..4678359	11848

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12322.13 Da
• Isoelectric Point: 7.8219

>T90075 WP_000132619.1 NZ_CP025317:c4671088-4670747 [Escherichia albertii]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAPEESE
LMQSLRQVCKLSARKQKQVQEFIGVIAGKQKVA

Nucleotide

• Length: 342 bp

>T90075 NZ_CP025317:c4671088-4670747 [Escherichia albertii]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGCCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCCCCGAAGAGAGCGAA
CTGATGCAGTCGCTACGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAGAAGCAGGTGCAGGAGTTTATTGGGGTGATTGC
CGGTAAACAGAAAGTCGCGTAA

Antitoxin

Nucleotide

• Length: 77 bp

>AT90075 NZ_CP025317:4671083-4671159 [Escherichia albertii]
AGTCATAACTGCTATTCTCCGATAATAGTGATTGTGATGAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Antitoxin