Detailed information of TA system TA090068

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): prlF-yhaV (relBE)/YhaV-PrlF
• Location: 3291226..3292025
• Replicon: chromosome
• Accession: NZ_CP025317
• Organism: Escherichia albertii strain 1551-2

Toxin (Protein)

• Gene name: yhaV
• Uniprot ID: A0A8H9C2I0
• Locus tag: CXP54_RS16675
• Protein ID: WP_059227548.1
• Coordinates: 3291561..3292025 (+)
• Length: 155 a.a.

Antitoxin (Protein)

• Gene name: prlF
• Uniprot ID: -
• Locus tag: CXP54_RS16670
• Protein ID: WP_103053959.1
• Coordinates: 3291226..3291561 (+)
• Length: 112 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CXP54_RS16655	3287015..3287785	-	771	WP_103053957.1	2-dehydro-3-deoxyglucarate aldolase	-
CXP54_RS16660	3287801..3289135	-	1335	WP_025238277.1	galactarate/glucarate/glycerate transporter GarP	-
CXP54_RS16665	3289506..3291077	+	1572	WP_103053958.1	galactarate dehydratase	-
CXP54_RS16670	3291226..3291561	+	336	WP_103053959.1	type II toxin-antitoxin system antitoxin PrlF	Antitoxin
CXP54_RS16675	3291561..3292025	+	465	WP_059227548.1	type II toxin-antitoxin system ribonuclease toxin YhaV	Toxin
CXP54_RS16680	3292080..3292889	-	810	WP_103053960.1	aga operon transcriptional regulator AgaR	-
CXP54_RS16690	3293138..3294418	+	1281	WP_059227551.1	tagatose-bisphosphate aldolase subunit KbaZ	-
CXP54_RS16695	3294441..3294914	+	474	WP_002461030.1	PTS N-acetylgalactosamine transporter subunit IIB	-
CXP54_RS16700	3294925..3295704	+	780	WP_000406226.1	PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC	-
CXP54_RS16705	3295694..3296572	+	879	WP_001295548.1	PTS system mannose/fructose/sorbose family transporter subunit IID	-
CXP54_RS16710	3296590..3297024	+	435	WP_000948824.1	PTS sugar transporter subunit IIA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin endonuclease, YhaV (12-150)

Antitoxin

• PrlF antitoxin (14-110)

Sequences

Toxin

Protein

• Length: 155 a.a.
• Molecular weight: 17819.26 Da
• Isoelectric Point: 9.7301

>T90068 WP_059227548.1 NZ_CP025317:3291561-3292025 [Escherichia albertii]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRFRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTQETEEKH

Nucleotide

• Length: 465 bp

>T90068 NZ_CP025317:3291561-3292025 [Escherichia albertii]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAACCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTTTCGTCTCTTCTTTCGTTACAGCGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACACTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCAAGAGACAGAAGAAAAGCATTGA

Antitoxin

Protein

• Length: 112 a.a.
• Molecular weight: 12336.89 Da
• Isoelectric Point: 4.5392

>AT90068 WP_103053959.1 NZ_CP025317:3291226-3291561 [Escherichia albertii]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRQGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Nucleotide

• Length: 336 bp

>AT90068 NZ_CP025317:3291226-3291561 [Escherichia albertii]
ATGCCCGCTAATGCTCGCTCTAACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCTGGCCTGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACAGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCGACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA