Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 2830707..2830952 Replicon chromosome
Accession NZ_CP025317
Organism Escherichia albertii strain 1551-2

Toxin (Protein)


Gene name hokX Uniprot ID L4J2K8
Locus tag CXP54_RS14385 Protein ID WP_000956460.1
Coordinates 2830707..2830859 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name sokX
Locus tag -
Coordinates 2830904..2830952 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CXP54_RS14375 2826522..2829179 - 2658 WP_123057910.1 CRISPR-associated helicase Cas3' -
CXP54_RS14380 2829432..2830543 + 1112 Protein_2665 IS4 family transposase -
CXP54_RS14385 2830707..2830859 - 153 WP_000956460.1 type I toxin-antitoxin system Hok family toxin Toxin
- 2830904..2830952 + 49 - - Antitoxin
CXP54_RS14395 2831123..2831857 - 735 WP_059228192.1 phosphoadenosine phosphosulfate reductase -
CXP54_RS14405 2831942..2833654 - 1713 WP_103053840.1 assimilatory sulfite reductase (NADPH) hemoprotein subunit -
CXP54_RS14410 2833654..2835453 - 1800 WP_103053841.1 NADPH-dependent assimilatory sulfite reductase flavoprotein subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(5-46)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5602.81 Da        Isoelectric Point: 7.7899

>T90064 WP_000956460.1 NZ_CP025317:c2830859-2830707 [Escherichia albertii]
MLTKYALVAIIVLCFTVLGFTLMVGDSLCELSIRERGMEFKAVLAYESKK

Download         Length: 153 bp

>T90064 NZ_CP025317:c2830859-2830707 [Escherichia albertii]
ATGCTGACAAAATATGCCCTTGTGGCAATCATAGTGCTGTGTTTCACGGTGCTGGGATTCACGCTGATGGTAGGCGACTC
GCTGTGTGAGTTGAGTATCAGAGAACGTGGTATGGAGTTTAAGGCAGTTCTCGCTTACGAATCGAAGAAGTAG

Antitoxin


Download         Length: 49 bp

>AT90064 NZ_CP025317:2830904-2830952 [Escherichia albertii]
GTTCGAACGTAGGCCTCAGGTTGATAGAAATATCGCCTGGGGCTTTTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829G7J5

Antitoxin

Download structure file

References