Detailed information of TA system TA090052

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 1508162..1508724
• Replicon: chromosome
• Accession: NZ_CP025317
• Organism: Escherichia albertii strain 1551-2

Toxin (Protein)

• Gene name: higB
• Uniprot ID: L4J948
• Locus tag: CXP54_RS07600
• Protein ID: WP_000605676.1
• Coordinates: 1508446..1508724 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: A0A8D9UMF3
• Locus tag: CXP54_RS07595
• Protein ID: WP_021528209.1
• Coordinates: 1508162..1508446 (-)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CXP54_RS07580	1503344..1506391	+	3048	WP_158649888.1	formate dehydrogenase-N subunit alpha	-
CXP54_RS07585	1506404..1507288	+	885	WP_001240583.1	formate dehydrogenase N subunit beta	-
CXP54_RS07590	1507281..1507934	+	654	WP_000045636.1	formate dehydrogenase-N subunit gamma	-
CXP54_RS07595	1508162..1508446	-	285	WP_021528209.1	HigA family addiction module antidote protein	Antitoxin
CXP54_RS07600	1508446..1508724	-	279	WP_000605676.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CXP54_RS07605	1508910..1509920	-	1011	WP_000642385.1	alcohol dehydrogenase AdhP	-
CXP54_RS07610	1510055..1511752	-	1698	WP_000433442.1	malate dehydrogenase	-
CXP54_RS07620	1511909..1512046	-	138	WP_000841563.1	stationary-phase-induced ribosome-associated protein	-
CXP54_RS07630	1512304..1512735	+	432	WP_000152289.1	peroxiredoxin OsmC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (4-92)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-65)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10521.10 Da
• Isoelectric Point: 7.3562

>T90052 WP_000605676.1 NZ_CP025317:c1508724-1508446 [Escherichia albertii]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAASCLADIDMPGYRLHPLSGDRDGIWAISVSGNWRITFEFVN
GDAYILDYEDYH

Nucleotide

• Length: 279 bp

>T90052 NZ_CP025317:c1508724-1508446 [Escherichia albertii]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCACCGACTCGCTGTGATTGATGCAGCAAGCTGTCTTGCTGATATCGATATGCCCGGTTACCGACTAC
ACCCATTAAGCGGCGATCGCGATGGCATCTGGGCAATATCTGTATCAGGCAACTGGCGAATCACGTTTGAGTTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10429.14 Da
• Isoelectric Point: 8.8567

>AT90052 WP_021528209.1 NZ_CP025317:c1508446-1508162 [Escherichia albertii]
MKMVNHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVTQ

Nucleotide

• Length: 285 bp

>AT90052 NZ_CP025317:c1508446-1508162 [Escherichia albertii]
ATGAAAATGGTCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAACTGAACGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCAACGGCAAGCCGACTGTTGACCGGAAAAGCGGCTTTGACGCCAGAAATGGCGA
TTAAACTTTCCGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAATGCCTGGAGTCTGGCAGAGGCTGAG
AAAACGGTGGATGTGTCGCGGTTGCGCCGTCTGGTGACGCAATAA

Structures

Toxin

• AlphaFold DB: A0A829G6T1