Detailed information of TA system TA090026

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 4896588..4897177
• Replicon: chromosome
• Accession: NZ_CP025272
• Organism: Xanthomonas vasicola pv. vasculorum strain Xv1601

Toxin (Protein)

• Gene name: graT
• Uniprot ID: A0A836P236
• Locus tag: CXP37_RS22635
• Protein ID: WP_010364341.1
• Coordinates: 4896896..4897177 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: graA
• Uniprot ID: -
• Locus tag: CXP37_RS22630
• Protein ID: WP_010364340.1
• Coordinates: 4896588..4896878 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CXP37_RS22595	4892034..4892516	-	483	WP_050560850.1	nuclear transport factor 2 family protein	-
CXP37_RS22600	4892681..4892950	-	270	WP_017112541.1	hypothetical protein	-
CXP37_RS22605	4893246..4893584	+	339	WP_010364330.1	hypothetical protein	-
CXP37_RS22620	4894231..4895625	-	1395	WP_026112228.1	nucleoside hydrolase	-
CXP37_RS22625	4895912..4896277	-	366	Protein_4174	hypothetical protein	-
CXP37_RS22630	4896588..4896878	-	291	WP_010364340.1	HigA family addiction module antidote protein	Antitoxin
CXP37_RS22635	4896896..4897177	-	282	WP_010364341.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CXP37_RS22640	4897279..4899516	-	2238	WP_087910933.1	exodeoxyribonuclease V subunit alpha	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (16-92)

Antitoxin

• Cro/C1-type helix-turn-helix domain (21-68)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 11005.68 Da
• Isoelectric Point: 9.7969

>T90026 WP_010364341.1 NZ_CP025272:c4897177-4896896 [Xanthomonas vasicola pv. vasculorum]
MIRSVIDKEAEKNWLGERSRRLPADMQTVARRKLRMLNAAAHLDDLRIPPANRLEALKGERRGQYSIRINDQWRICFRWM
EGDVAEVEIVDYP

Nucleotide

• Length: 282 bp

>T90026 NZ_CP025272:c4897177-4896896 [Xanthomonas vasicola pv. vasculorum]
ATGATCAGGAGCGTTATCGACAAGGAAGCCGAAAAGAACTGGCTGGGTGAGCGTTCCCGGCGATTGCCGGCCGATATGCA
GACGGTCGCGCGCCGCAAGTTGCGCATGCTCAACGCCGCCGCACACCTGGATGATTTACGCATTCCGCCTGCCAACCGGC
TAGAAGCATTGAAGGGCGAGCGGCGCGGCCAGTACAGCATCCGGATCAACGACCAATGGCGCATCTGCTTCCGATGGATG
GAGGGCGATGTGGCTGAGGTCGAAATCGTCGATTACCCATGA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10453.10 Da
• Isoelectric Point: 6.4675

>AT90026 WP_010364340.1 NZ_CP025272:c4896878-4896588 [Xanthomonas vasicola pv. vasculorum]
MAVLPNIHPGEILFEEFLEPLGISQNALARATGVPPRRINEIVLGKRGITADTAVRLAAALGTTERFWLGLQADYELEEA
HRALGDLPARIKRLAA

Nucleotide

• Length: 291 bp

>AT90026 NZ_CP025272:c4896878-4896588 [Xanthomonas vasicola pv. vasculorum]
ATGGCCGTCCTACCCAACATCCACCCTGGCGAAATTCTGTTTGAGGAGTTTCTCGAACCTCTCGGTATCAGCCAGAACGC
GCTGGCGCGGGCTACCGGCGTACCACCGCGCCGCATCAACGAAATCGTGCTGGGCAAGCGCGGCATCACCGCCGACACCG
CCGTGCGCTTGGCCGCCGCGTTAGGAACGACTGAGCGCTTCTGGTTGGGCCTGCAGGCCGACTACGAACTGGAAGAGGCG
CATCGCGCGCTGGGCGATTTGCCGGCGCGGATCAAGCGGCTGGCGGCATGA

Structures

Toxin

• AlphaFold DB: A0A836P236