89969

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1703473..1704141 Replicon chromosome
Accession NZ_CP025256
Organism Streptococcus pneumoniae strain Xen35

Toxin (Protein)


Gene name hicA Uniprot ID A0A0B7M7X4
Locus tag CXP32_RS08955 Protein ID WP_001132284.1
Coordinates 1703962..1704141 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID G0IC64
Locus tag CXP32_RS08950 Protein ID WP_000961810.1
Coordinates 1703473..1703925 (-) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CXP32_RS08925 1699365..1700108 - 744 WP_001188203.1 16S rRNA (uracil(1498)-N(3))-methyltransferase -
CXP32_RS08930 1700110..1701060 - 951 WP_000451153.1 50S ribosomal protein L11 methyltransferase -
CXP32_RS08935 1701196..1701624 - 429 WP_000418173.1 NUDIX hydrolase -
CXP32_RS08940 1701605..1702693 - 1089 WP_000719713.1 M50 family metallopeptidase -
CXP32_RS08945 1702712..1703182 - 471 WP_000257087.1 DUF3013 family protein -
CXP32_RS08950 1703473..1703925 - 453 WP_000961810.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
CXP32_RS08955 1703962..1704141 - 180 WP_001132284.1 type II toxin-antitoxin system HicA family toxin Toxin
CXP32_RS08960 1704278..1704457 - 180 WP_001048906.1 hypothetical protein -
CXP32_RS08970 1704622..1704837 - 216 WP_075329187.1 hypothetical protein -
CXP32_RS08975 1705135..1706406 + 1272 WP_001113214.1 replication-associated recombination protein A -
CXP32_RS12110 1706826..1706942 - 117 WP_001855795.1 hypothetical protein -
CXP32_RS08990 1706963..1708219 - 1257 WP_000436400.1 ISL3 family transposase -
CXP32_RS08995 1708525..1709100 - 576 WP_000810872.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 1706963..1708219 1256


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-114)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6713.95 Da        Isoelectric Point: 11.0174

>T89969 WP_001132284.1 NZ_CP025256:c1704141-1703962 [Streptococcus pneumoniae]
MPMTQKEMVKLLTAHGWIKTRGGKGSHIKMEKQGERPITILHGELNKYTERGIRKQAGL

Download         Length: 180 bp

>T89969 NZ_CP025256:c1704141-1703962 [Streptococcus pneumoniae]
ATGCCTATGACACAAAAAGAGATGGTTAAACTCCTTACGGCCCATGGTTGGATAAAGACTAGAGGCGGTAAAGGCTCCCA
TATTAAAATGGAAAAGCAAGGGGAAAGACCTATCACAATCCTTCATGGTGAGCTGAATAAGTACACTGAAAGAGGGATAA
GAAAGCAAGCTGGGTTGTAA

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16659.46 Da        Isoelectric Point: 3.7220

>AT89969 WP_000961810.1 NZ_CP025256:c1703925-1703473 [Streptococcus pneumoniae]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Download         Length: 453 bp

>AT89969 NZ_CP025256:c1703925-1703473 [Streptococcus pneumoniae]
ATGTTAGTTACGTATCCAGCTTTATTTTATTATGACGACACAGACGGAACAGAAGCGACTTATTTTGTCCATTTCCCAGA
TTTTGAATACTCAGCTACACAAGGAGAGGGGATTTCTGAGGCTTTGGCTATGGGGTCGGAGTGGCTAGGGATAACTGTTG
CAGATTTGATAGAGAGTGATGGAGAGTTACCTCAGCCATCAGATATCAATAGCTTGTCTTTAATTGATAATGATCCTTTT
AAAGATGATGAAGATTTCGTGTCAACCTATGACCTTGATAAATCTTTTATTTCTATGGTATCTGTTGATGTATCAGAATA
CCTAGGAAGTCAGGAACCCATTAAAAAGACTTTGACCATACCAAAATGGGCAGATAAGTTGGGACGAGAAATGGGGCTTA
ACTTTTCTCAGACTTTGACAGACGCTATTGCAGATAAGAAAGTTCAAGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B7M7X4

Antitoxin

Source ID Structure
PDB 5YRZ
AlphaFold DB G0IC64

References