89968

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1644833..1645345 Replicon chromosome
Accession NZ_CP025256
Organism Streptococcus pneumoniae strain Xen35

Toxin (Protein)


Gene name yoeB Uniprot ID Q8DNR3
Locus tag CXP32_RS08690 Protein ID WP_000924721.1
Coordinates 1644833..1645087 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID K0ZY22
Locus tag CXP32_RS08695 Protein ID WP_000388572.1
Coordinates 1645091..1645345 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CXP32_RS08675 1641934..1642248 - 315 WP_000979235.1 DNA-directed RNA polymerase subunit omega -
CXP32_RS08680 1642273..1642899 - 627 WP_000775037.1 guanylate kinase -
CXP32_RS08685 1643029..1644642 - 1614 WP_000404940.1 ribonuclease Y -
CXP32_RS08690 1644833..1645087 - 255 WP_000924721.1 Txe/YoeB family addiction module toxin Toxin
CXP32_RS08695 1645091..1645345 - 255 WP_000388572.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CXP32_RS08700 1645583..1646680 - 1098 WP_000156358.1 nucleotidyltransferase -
CXP32_RS08705 1646690..1647436 - 747 WP_000605157.1 class I SAM-dependent methyltransferase -
CXP32_RS08710 1647539..1647892 - 354 WP_001003023.1 ribosome silencing factor -
CXP32_RS08715 1647905..1648405 - 501 WP_000844707.1 cysteine hydrolase -
CXP32_RS08720 1648406..1648999 - 594 WP_000121667.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) YqeK -
CXP32_RS08725 1648999..1649628 - 630 WP_000151313.1 nicotinate-nucleotide adenylyltransferase -
CXP32_RS08730 1649680..1649991 - 312 WP_000060169.1 ribosome assembly RNA-binding protein YhbY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-75)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10115.55 Da        Isoelectric Point: 7.9716

>T89968 WP_000924721.1 NZ_CP025256:c1645087-1644833 [Streptococcus pneumoniae]
MLLKFTEDAWADYCYWQNQDKKTLKRINKLIKDIQRDPFTGIGKPEPLKYDYQGAWSRRIDAENRLIYMMDGDSVAFLSF
KDHY

Download         Length: 255 bp

>T89968 NZ_CP025256:c1645087-1644833 [Streptococcus pneumoniae]
ATGCTGCTCAAGTTTACAGAAGATGCCTGGGCAGATTATTGCTACTGGCAAAATCAGGATAAGAAAACGTTAAAAAGAAT
CAATAAACTAATCAAGGATATTCAACGTGATCCCTTTACAGGAATAGGTAAACCAGAACCACTCAAATATGATTACCAAG
GAGCCTGGTCACGGCGTATTGATGCAGAAAATCGCTTGATTTATATGATGGATGGAGATAGCGTGGCTTTCTTGTCCTTT
AAAGATCATTACTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9706.00 Da        Isoelectric Point: 4.8430

>AT89968 WP_000388572.1 NZ_CP025256:c1645345-1645091 [Streptococcus pneumoniae]
MEAVLYSTFRNHLKDYMKKVNDEFEPLTVVNKNPDEDIVVLSKSEWDSIQETLRIAQNKELSDKVLRGMAQVRAGSTQVH
VIEE

Download         Length: 255 bp

>AT89968 NZ_CP025256:c1645345-1645091 [Streptococcus pneumoniae]
ATGGAAGCAGTCCTTTACTCAACATTCCGAAATCATTTAAAGGACTACATGAAGAAGGTAAATGATGAATTTGAGCCTTT
GACGGTGGTCAATAAAAATCCAGATGAGGACATTGTAGTCCTTTCAAAGAGTGAGTGGGATAGTATCCAAGAAACCCTGA
GAATTGCTCAAAATAAGGAACTTTCTGATAAGGTTTTGCGAGGAATGGCTCAAGTTCGTGCTGGAAGTACTCAGGTCCAT
GTTATTGAGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B7LEN4

Antitoxin

Source ID Structure
AlphaFold DB K0ZY22

References