Detailed information of TA system TA089952

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 3983767..3983989
• Replicon: chromosome
• Accession: NZ_CP025251
• Organism: Escherichia coli strain BH100 substr. MG2017

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1NWX0
• Locus tag: BH100B_RS20270
• Protein ID: WP_001295224.1
• Coordinates: 3983767..3983874 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	3983923..3983989 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BH100B_RS20245	3979020..3979772	-	753	Protein_3706	cellulose biosynthesis protein BcsQ	-
BH100B_RS20250	3979784..3979972	-	189	WP_001063314.1	YhjR family protein	-
BH100B_RS20255	3980245..3981816	+	1572	WP_001204945.1	cellulose biosynthesis protein BcsE	-
BH100B_RS20260	3981813..3982004	+	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
BH100B_RS20265	3982001..3983680	+	1680	WP_000191565.1	cellulose biosynthesis protein BcsG	-
BH100B_RS20270	3983767..3983874	-	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
-	3983923..3983989	+	67	-	-	Antitoxin
BH100B_RS20285	3984350..3985621	+	1272	WP_001298005.1	amino acid permease	-
BH100B_RS20290	3985651..3986655	-	1005	WP_000103577.1	dipeptide ABC transporter ATP-binding subunit DppF	-
BH100B_RS20295	3986652..3987635	-	984	WP_001196477.1	dipeptide ABC transporter ATP-binding protein	-
BH100B_RS20300	3987646..3988548	-	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3882.70 Da
• Isoelectric Point: 9.0157

>T89952 WP_001295224.1 NZ_CP025251:c3983874-3983767 [Escherichia coli]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T89952 NZ_CP025251:c3983874-3983767 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin

Nucleotide

• Length: 67 bp

>AT89952 NZ_CP025251:3983923-3983989 [Escherichia coli]
GTCTAGGTTCAAGATTAGCCCCCGTGATATTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Structures

Toxin

• AlphaFold DB: A0A4P7TSJ7

Antitoxin