Detailed information of TA system TA089866

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 3212696..3213365
• Replicon: chromosome
• Accession: NZ_CP025198
• Organism: Acidipropionibacterium virtanenii strain JS278

Toxin (Protein)

• Gene name: HigB2
• Uniprot ID: -
• Locus tag: JS278_RS14835
• Protein ID: WP_114045864.1
• Coordinates: 3213012..3213365 (-)
• Length: 118 a.a.

Antitoxin (Protein)

• Gene name: HigA2
• Uniprot ID: -
• Locus tag: JS278_RS14830
• Protein ID: WP_114045863.1
• Coordinates: 3212696..3213010 (-)
• Length: 105 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JS278_RS14825	3208228..3211668	-	3441	WP_114045862.1	AAA family ATPase	-
JS278_RS16095	3211889..3212059	+	171	WP_181833760.1	hypothetical protein	-
JS278_RS14830	3212696..3213010	-	315	WP_114045863.1	helix-turn-helix domain-containing protein	Antitoxin
JS278_RS14835	3213012..3213365	-	354	WP_114045864.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JS278_RS14840	3213384..3214394	-	1011	WP_114045865.1	restriction endonuclease	-
JS278_RS14845	3216018..3218045	-	2028	WP_114045866.1	GNAT family N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (11-106)

Antitoxin

• Cro/C1-type helix-turn-helix domain (38-87)

Sequences

Toxin

Protein

• Length: 118 a.a.
• Molecular weight: 13560.53 Da
• Isoelectric Point: 8.7448

>T89866 WP_114045864.1 NZ_CP025198:c3213365-3213012 [Acidipropionibacterium virtanenii]
MWVVDVALIQDWLDDLDRASWRQVIAALQVLRDHGPQLGRPLLDTVVGSRHTNMKELRPGSAGRSELRILFAFDPRRQAI
LLVAGDKQGNWSRWYKENLPVADDLLDEHLRALRERR

Nucleotide

• Length: 354 bp

>T89866 NZ_CP025198:c3213365-3213012 [Acidipropionibacterium virtanenii]
ATGTGGGTCGTCGATGTTGCCCTGATCCAGGACTGGCTCGACGACCTCGATCGTGCGTCCTGGCGACAGGTGATCGCCGC
ACTGCAGGTGCTGCGAGATCACGGTCCACAGCTCGGCCGTCCACTCCTGGACACTGTGGTCGGTTCGAGACACACGAACA
TGAAGGAACTGCGACCAGGATCTGCTGGGCGCTCCGAGCTCCGGATCCTGTTCGCATTCGATCCGCGTCGTCAGGCGATT
CTGCTTGTGGCAGGGGACAAGCAGGGGAACTGGTCGCGGTGGTACAAGGAGAATCTTCCGGTCGCAGACGATCTGCTCGA
TGAGCATCTTCGTGCGTTGAGGGAAAGGCGATGA

Antitoxin

Protein

• Length: 105 a.a.
• Molecular weight: 11489.05 Da
• Isoelectric Point: 6.4753

>AT89866 WP_114045863.1 NZ_CP025198:c3213010-3212696 [Acidipropionibacterium virtanenii]
MSLALDEYLAKHPVTPEDQAAIDAHKATMLAEVRAYRLRELRERAGLTQAQLAERIGVGQRQVSKIERGDLDSARVGTIR
KYLEAVGGQLAVEYVSGDERLQVA

Nucleotide

• Length: 315 bp

>AT89866 NZ_CP025198:c3213010-3212696 [Acidipropionibacterium virtanenii]
ATGTCTCTGGCACTTGATGAATATCTGGCCAAGCATCCAGTGACGCCTGAGGATCAGGCGGCGATCGACGCCCACAAGGC
GACCATGCTTGCCGAGGTCCGCGCGTACCGTTTGCGCGAGTTGCGGGAGCGAGCCGGGCTCACCCAAGCCCAGCTCGCCG
AGCGGATCGGAGTTGGACAGCGCCAGGTCTCGAAGATCGAACGAGGCGACCTCGACAGTGCGCGCGTCGGCACGATTCGC
AAGTACCTCGAGGCAGTCGGGGGACAGCTCGCAGTGGAGTACGTCAGCGGCGACGAGCGCCTGCAGGTCGCTTGA