Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3122156..3122834 Replicon chromosome
Accession NZ_CP025198
Organism Acidipropionibacterium virtanenii strain JS278

Toxin (Protein)


Gene name HigB2 Uniprot ID -
Locus tag JS278_RS14435 Protein ID WP_114045801.1
Coordinates 3122481..3122834 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name HigA2 Uniprot ID -
Locus tag JS278_RS14430 Protein ID WP_114045800.1
Coordinates 3122156..3122479 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JS278_RS14410 3117770..3118822 + 1053 WP_114046041.1 ISAs1 family transposase -
JS278_RS14415 3118891..3120086 + 1196 Protein_2819 IS3 family transposase -
JS278_RS14420 3120356..3121087 - 732 WP_114045798.1 TetR/AcrR family transcriptional regulator C-terminal domain-containing protein -
JS278_RS14425 3121154..3121534 + 381 WP_114045799.1 VOC family protein -
JS278_RS14430 3122156..3122479 - 324 WP_114045800.1 XRE family transcriptional regulator Antitoxin
JS278_RS14435 3122481..3122834 - 354 WP_114045801.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JS278_RS14440 3123326..3123965 + 640 Protein_2824 transposase -
JS278_RS14445 3124255..3124848 - 594 WP_114045802.1 TetR family transcriptional regulator -
JS278_RS14450 3124986..3125306 - 321 WP_114046362.1 MmcQ/YjbR family DNA-binding protein -
JS278_RS14455 3125372..3125767 - 396 WP_114045803.1 MmcQ/YjbR family DNA-binding protein -
JS278_RS14460 3125932..3126909 + 978 WP_114046363.1 zinc-binding dehydrogenase -
JS278_RS14465 3126975..3127433 + 459 WP_114045804.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3123594..3123968 374


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-108)

Antitoxin

HigA2-like, helix-turn-helix domain

(36-95)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13375.30 Da        Isoelectric Point: 8.5886

>T89865 WP_114045801.1 NZ_CP025198:c3122834-3122481 [Acidipropionibacterium virtanenii]
MPWEVRLWEDVESWVLALDDVTYNLVAAAIARLEAVGPALGRPTADRIKGSRHHNMKELRPGSAGRREIRILFAFDPKRR
AILLVAGDKSGRWRQWYAKNVPVADARLDEWLSAEEE

Download         Length: 354 bp

>T89865 NZ_CP025198:c3122834-3122481 [Acidipropionibacterium virtanenii]
ATGCCGTGGGAGGTTCGCTTATGGGAGGATGTCGAGTCATGGGTCCTCGCTCTGGATGACGTGACCTACAACTTGGTTGC
CGCCGCGATCGCTCGTCTGGAGGCTGTGGGGCCGGCACTTGGGCGCCCAACAGCGGATCGCATCAAAGGATCTCGCCATC
ACAACATGAAGGAGCTTCGTCCTGGGTCAGCGGGACGAAGAGAGATCCGTATCCTGTTCGCCTTCGACCCGAAACGACGA
GCCATCCTCTTGGTGGCTGGTGACAAGTCGGGGCGTTGGCGGCAGTGGTACGCCAAGAACGTTCCCGTAGCCGATGCCAG
ACTCGACGAGTGGCTGAGCGCAGAGGAGGAGTGA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 11793.33 Da        Isoelectric Point: 5.7698

>AT89865 WP_114045800.1 NZ_CP025198:c3122479-3122156 [Acidipropionibacterium virtanenii]
MPESRTVAWQGVRAKRPVDEAAVAGHVARMEAEERAYRLREIREEQGVTQKQLAERMHLTQPTISALESGDLDRSGLATL
KSYVEALGGTIEVVATFGDRKLVVSSE

Download         Length: 324 bp

>AT89865 NZ_CP025198:c3122479-3122156 [Acidipropionibacterium virtanenii]
ATGCCCGAATCAAGAACTGTGGCGTGGCAGGGTGTCCGTGCCAAGAGGCCCGTCGACGAGGCCGCCGTCGCTGGGCATGT
CGCGCGGATGGAAGCCGAGGAACGGGCCTACCGTTTGCGCGAGATCCGTGAGGAGCAGGGCGTCACCCAGAAGCAGCTCG
CCGAACGCATGCACTTGACCCAGCCAACGATCTCGGCGCTGGAGTCCGGCGATCTGGATCGATCAGGACTGGCCACGCTC
AAGTCCTACGTCGAGGCGCTCGGGGGAACCATCGAAGTTGTCGCCACCTTTGGCGACCGCAAACTCGTGGTCTCCTCAGA
ATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References