Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 2444039..2444629 Replicon chromosome
Accession NZ_CP025198
Organism Acidipropionibacterium virtanenii strain JS278

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag JS278_RS11320 Protein ID WP_114045286.1
Coordinates 2444348..2444629 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag JS278_RS11315 Protein ID WP_114045285.1
Coordinates 2444039..2444338 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JS278_RS11270 2439127..2439696 - 570 WP_114045276.1 dihydrofolate reductase family protein -
JS278_RS11275 2439767..2440324 + 558 WP_114045277.1 dihydrofolate reductase family protein -
JS278_RS11280 2440328..2440744 - 417 WP_114045278.1 type II toxin-antitoxin system VapC family toxin -
JS278_RS11285 2440741..2441022 - 282 WP_114045279.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
JS278_RS11290 2441066..2441602 - 537 WP_114045280.1 GNAT family N-acetyltransferase -
JS278_RS11295 2441666..2442160 + 495 WP_114045281.1 tetratricopeptide repeat protein -
JS278_RS11300 2442178..2442987 - 810 WP_114045282.1 GNAT family N-acetyltransferase -
JS278_RS11305 2443064..2443492 + 429 WP_114045283.1 GNAT family N-acetyltransferase -
JS278_RS11310 2443608..2444042 - 435 WP_114045284.1 hypothetical protein -
JS278_RS11315 2444039..2444338 - 300 WP_114045285.1 HigA family addiction module antidote protein Antitoxin
JS278_RS11320 2444348..2444629 - 282 WP_114045286.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JS278_RS11325 2444731..2445051 - 321 WP_114045287.1 HigA family addiction module antidote protein -
JS278_RS11330 2445026..2445307 - 282 Protein_2216 type II toxin-antitoxin system RelE/ParE family toxin -
JS278_RS11335 2445470..2445667 + 198 WP_114045288.1 hypothetical protein -
JS278_RS11340 2445664..2445999 + 336 WP_114046290.1 type II toxin-antitoxin system PemK/MazF family toxin -
JS278_RS11345 2446145..2447218 - 1074 WP_114045289.1 redox-regulated ATPase YchF -
JS278_RS11350 2447278..2448192 + 915 WP_114045290.1 VOC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(7-84)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10897.41 Da        Isoelectric Point: 9.3241

>T89862 WP_114045286.1 NZ_CP025198:c2444629-2444348 [Acidipropionibacterium virtanenii]
VIRSFADRGTERVWRRESAKRLDPRIHKVADRKLHLLDTATVLDAQRVPPGNRLVLLKGDRAEQHSIRINDQWRICFCWT
DAGPEDVQIVDYH

Download         Length: 282 bp

>T89862 NZ_CP025198:c2444629-2444348 [Acidipropionibacterium virtanenii]
GTGATCAGATCGTTCGCTGACCGTGGCACCGAGCGGGTGTGGCGGCGTGAGTCGGCGAAGCGACTCGATCCGCGCATCCA
CAAGGTCGCCGACAGGAAGCTGCATCTGTTGGACACAGCGACAGTGCTGGACGCGCAGCGCGTGCCGCCCGGCAACCGTC
TGGTACTGCTCAAGGGTGACAGAGCCGAGCAGCACAGCATTCGCATCAACGATCAATGGCGGATCTGCTTTTGCTGGACT
GACGCCGGTCCCGAAGATGTGCAGATCGTCGACTACCACTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11183.95 Da        Isoelectric Point: 6.2218

>AT89862 WP_114045285.1 NZ_CP025198:c2444338-2444039 [Acidipropionibacterium virtanenii]
MSEKLYPPIHPGEVLMEDFIEGFGITQHKLAVAIGVPPRRINEIVHGKRAITADTALRLGRYFGMDPQFWLNLQTRYELE
IAEDRVADQVAAITPLRVA

Download         Length: 300 bp

>AT89862 NZ_CP025198:c2444338-2444039 [Acidipropionibacterium virtanenii]
ATGTCCGAGAAGCTCTATCCGCCGATCCACCCGGGCGAGGTCCTCATGGAGGACTTCATCGAGGGGTTCGGCATCACGCA
GCACAAGCTCGCCGTGGCGATCGGGGTGCCGCCGCGCCGGATCAACGAGATCGTCCATGGCAAGCGAGCGATCACCGCGG
ACACTGCGTTGCGCCTGGGGCGCTACTTCGGGATGGATCCCCAGTTCTGGCTCAACCTTCAGACGCGGTACGAGTTGGAG
ATCGCCGAGGATCGCGTCGCCGATCAGGTCGCGGCGATCACGCCGCTCCGGGTCGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References