Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
| Location | 53482..54139 | Replicon | plasmid KP1766_p1 |
| Accession | NZ_CP025147 | ||
| Organism | Klebsiella pneumoniae strain KP1766 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | U3PDC3 |
| Locus tag | CXB26_RS27475 | Protein ID | WP_000270043.1 |
| Coordinates | 53482..53832 (+) | Length | 117 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | CXB26_RS27480 | Protein ID | WP_000124640.1 |
| Coordinates | 53837..54139 (+) | Length | 101 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CXB26_RS27435 | 49956..50453 | - | 498 | WP_000062185.1 | hypothetical protein | - |
| CXB26_RS27440 | 50456..50944 | - | 489 | WP_001273096.1 | DUF1643 domain-containing protein | - |
| CXB26_RS27445 | 51041..51376 | + | 336 | WP_000683476.1 | hypothetical protein | - |
| CXB26_RS27450 | 51391..51861 | - | 471 | WP_001281821.1 | hypothetical protein | - |
| CXB26_RS27455 | 51854..52225 | - | 372 | WP_000516916.1 | hypothetical protein | - |
| CXB26_RS27460 | 52236..52430 | - | 195 | WP_000343597.1 | hypothetical protein | - |
| CXB26_RS27470 | 52771..53319 | - | 549 | WP_001061574.1 | transcriptional regulator | - |
| CXB26_RS27475 | 53482..53832 | + | 351 | WP_000270043.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| CXB26_RS27480 | 53837..54139 | + | 303 | WP_000124640.1 | XRE family transcriptional regulator | Antitoxin |
| CXB26_RS27485 | 54166..54459 | - | 294 | WP_001239997.1 | chromosome segregation protein ParM | - |
| CXB26_RS27490 | 54547..54819 | - | 273 | WP_001043047.1 | HU family DNA-binding protein | - |
| CXB26_RS27495 | 54877..55422 | - | 546 | WP_032413569.1 | thermonuclease family protein | - |
| CXB26_RS27505 | 55546..56526 | - | 981 | WP_012569499.1 | IS5-like element ISKpn26 family transposase | - |
| CXB26_RS27515 | 56835..57692 | - | 858 | WP_001167032.1 | hypothetical protein | - |
| CXB26_RS27520 | 57679..57909 | - | 231 | WP_000972663.1 | hypothetical protein | - |
| CXB26_RS27525 | 57909..58427 | - | 519 | WP_000210758.1 | nitrite reductase | - |
| CXB26_RS27530 | 58424..58870 | - | 447 | WP_000919345.1 | Fe3+-siderophore ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | sul2 / blaKPC-2 / sul1 / qacE / aac(6')-33 / ant(2'')-Ia / blaTEM-1D | - | 1..205953 | 205953 | |
| - | flank | IS/Tn | - | - | 55546..56526 | 980 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 13328.21 Da Isoelectric Point: 5.2421
>T89852 WP_000270043.1 NZ_CP025147:53482-53832 [Klebsiella pneumoniae]
MWVIETTDTFDEWFDALDDTDRANVLASMMVLRDRGPMLSRPYADTVNGSSYSNMKELRVQSKGDPIRAFFAFDPKRKGI
LLCAGNKTGDEKRFYEVMIPIADREFAAHLDKLKKE
MWVIETTDTFDEWFDALDDTDRANVLASMMVLRDRGPMLSRPYADTVNGSSYSNMKELRVQSKGDPIRAFFAFDPKRKGI
LLCAGNKTGDEKRFYEVMIPIADREFAAHLDKLKKE
Download Length: 351 bp
>T89852 NZ_CP025147:53482-53832 [Klebsiella pneumoniae]
ATGTGGGTCATCGAGACAACCGACACCTTTGATGAGTGGTTCGATGCTCTGGATGATACCGATAGAGCAAACGTGCTGGC
TTCGATGATGGTGCTGCGAGATAGAGGCCCCATGCTGTCGAGGCCATACGCGGATACTGTTAACGGTTCATCCTACAGCA
ACATGAAAGAGCTTCGGGTCCAAAGCAAAGGAGATCCTATCAGAGCGTTCTTTGCGTTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGCGCCGGTAACAAGACCGGGGACGAGAAAAGGTTTTATGAAGTAATGATCCCAATTGCAGACCGTGAGTTTGC
GGCGCACTTGGATAAATTGAAGAAGGAGTGA
ATGTGGGTCATCGAGACAACCGACACCTTTGATGAGTGGTTCGATGCTCTGGATGATACCGATAGAGCAAACGTGCTGGC
TTCGATGATGGTGCTGCGAGATAGAGGCCCCATGCTGTCGAGGCCATACGCGGATACTGTTAACGGTTCATCCTACAGCA
ACATGAAAGAGCTTCGGGTCCAAAGCAAAGGAGATCCTATCAGAGCGTTCTTTGCGTTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGCGCCGGTAACAAGACCGGGGACGAGAAAAGGTTTTATGAAGTAATGATCCCAATTGCAGACCGTGAGTTTGC
GGCGCACTTGGATAAATTGAAGAAGGAGTGA
Antitoxin
Download Length: 101 a.a. Molecular weight: 11006.73 Da Isoelectric Point: 7.2036
>AT89852 WP_000124640.1 NZ_CP025147:53837-54139 [Klebsiella pneumoniae]
MARTLDQMLATEKPEVVAKAQKAATEMLLNIHLAELRDRMNLTQGEIAASLGVRQPTVSEMEKPGRDLKLSSIKRYVEAS
GGKLRLDVELPDGTHYGFAV
MARTLDQMLATEKPEVVAKAQKAATEMLLNIHLAELRDRMNLTQGEIAASLGVRQPTVSEMEKPGRDLKLSSIKRYVEAS
GGKLRLDVELPDGTHYGFAV
Download Length: 303 bp
>AT89852 NZ_CP025147:53837-54139 [Klebsiella pneumoniae]
ATGGCAAGAACTCTTGACCAAATGCTGGCAACAGAAAAGCCTGAGGTTGTTGCCAAAGCACAGAAAGCGGCCACTGAGAT
GTTACTGAACATCCACTTGGCAGAGCTTCGTGATCGCATGAACCTTACCCAGGGGGAAATTGCTGCATCTCTGGGTGTGA
GACAGCCGACAGTCTCCGAGATGGAAAAACCTGGACGAGATCTCAAGCTGTCGTCCATTAAGCGGTACGTTGAGGCCTCC
GGTGGCAAGCTACGCCTCGATGTTGAACTTCCGGACGGCACCCACTACGGCTTTGCCGTTTAA
ATGGCAAGAACTCTTGACCAAATGCTGGCAACAGAAAAGCCTGAGGTTGTTGCCAAAGCACAGAAAGCGGCCACTGAGAT
GTTACTGAACATCCACTTGGCAGAGCTTCGTGATCGCATGAACCTTACCCAGGGGGAAATTGCTGCATCTCTGGGTGTGA
GACAGCCGACAGTCTCCGAGATGGAAAAACCTGGACGAGATCTCAAGCTGTCGTCCATTAAGCGGTACGTTGAGGCCTCC
GGTGGCAAGCTACGCCTCGATGTTGAACTTCCGGACGGCACCCACTACGGCTTTGCCGTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|