Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
| Location | 48030..48687 | Replicon | plasmid NR5632_p1 |
| Accession | NZ_CP025144 | ||
| Organism | Klebsiella pneumoniae strain NR5632 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | U3PDC3 |
| Locus tag | CXB25_RS27460 | Protein ID | WP_000270043.1 |
| Coordinates | 48030..48380 (+) | Length | 117 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | CXB25_RS27465 | Protein ID | WP_000124640.1 |
| Coordinates | 48385..48687 (+) | Length | 101 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CXB25_RS27420 | 44504..45001 | - | 498 | WP_000062185.1 | hypothetical protein | - |
| CXB25_RS27425 | 45004..45492 | - | 489 | WP_001273096.1 | DUF1643 domain-containing protein | - |
| CXB25_RS27430 | 45589..45924 | + | 336 | WP_000683476.1 | hypothetical protein | - |
| CXB25_RS27435 | 45939..46409 | - | 471 | WP_001281821.1 | hypothetical protein | - |
| CXB25_RS27440 | 46402..46773 | - | 372 | WP_000516916.1 | hypothetical protein | - |
| CXB25_RS27445 | 46784..46978 | - | 195 | WP_000343597.1 | hypothetical protein | - |
| CXB25_RS27455 | 47319..47867 | - | 549 | WP_001061574.1 | transcriptional regulator | - |
| CXB25_RS27460 | 48030..48380 | + | 351 | WP_000270043.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| CXB25_RS27465 | 48385..48687 | + | 303 | WP_000124640.1 | XRE family transcriptional regulator | Antitoxin |
| CXB25_RS27470 | 48714..49007 | - | 294 | WP_001239997.1 | chromosome segregation protein ParM | - |
| CXB25_RS27475 | 49095..49367 | - | 273 | WP_001043047.1 | HU family DNA-binding protein | - |
| CXB25_RS27480 | 49425..49970 | - | 546 | WP_032413569.1 | thermonuclease family protein | - |
| CXB25_RS27490 | 50094..51074 | - | 981 | WP_012569499.1 | IS5-like element ISKpn26 family transposase | - |
| CXB25_RS27500 | 51383..52240 | - | 858 | WP_001167032.1 | hypothetical protein | - |
| CXB25_RS27505 | 52227..52457 | - | 231 | WP_000972663.1 | hypothetical protein | - |
| CXB25_RS27510 | 52457..52975 | - | 519 | WP_000210758.1 | nitrite reductase | - |
| CXB25_RS27515 | 52972..53418 | - | 447 | WP_000919345.1 | Fe3+-siderophore ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | sul2 / blaKPC-33 / sul1 / qacE / aac(6')-33 / ant(2'')-Ia / blaTEM-1D | - | 1..204123 | 204123 | |
| - | flank | IS/Tn | - | - | 50094..51074 | 980 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 13328.21 Da Isoelectric Point: 5.2421
>T89831 WP_000270043.1 NZ_CP025144:48030-48380 [Klebsiella pneumoniae]
MWVIETTDTFDEWFDALDDTDRANVLASMMVLRDRGPMLSRPYADTVNGSSYSNMKELRVQSKGDPIRAFFAFDPKRKGI
LLCAGNKTGDEKRFYEVMIPIADREFAAHLDKLKKE
MWVIETTDTFDEWFDALDDTDRANVLASMMVLRDRGPMLSRPYADTVNGSSYSNMKELRVQSKGDPIRAFFAFDPKRKGI
LLCAGNKTGDEKRFYEVMIPIADREFAAHLDKLKKE
Download Length: 351 bp
>T89831 NZ_CP025144:48030-48380 [Klebsiella pneumoniae]
ATGTGGGTCATCGAGACAACCGACACCTTTGATGAGTGGTTCGATGCTCTGGATGATACCGATAGAGCAAACGTGCTGGC
TTCGATGATGGTGCTGCGAGATAGAGGCCCCATGCTGTCGAGGCCATACGCGGATACTGTTAACGGTTCATCCTACAGCA
ACATGAAAGAGCTTCGGGTCCAAAGCAAAGGAGATCCTATCAGAGCGTTCTTTGCGTTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGCGCCGGTAACAAGACCGGGGACGAGAAAAGGTTTTATGAAGTAATGATCCCAATTGCAGACCGTGAGTTTGC
GGCGCACTTGGATAAATTGAAGAAGGAGTGA
ATGTGGGTCATCGAGACAACCGACACCTTTGATGAGTGGTTCGATGCTCTGGATGATACCGATAGAGCAAACGTGCTGGC
TTCGATGATGGTGCTGCGAGATAGAGGCCCCATGCTGTCGAGGCCATACGCGGATACTGTTAACGGTTCATCCTACAGCA
ACATGAAAGAGCTTCGGGTCCAAAGCAAAGGAGATCCTATCAGAGCGTTCTTTGCGTTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGCGCCGGTAACAAGACCGGGGACGAGAAAAGGTTTTATGAAGTAATGATCCCAATTGCAGACCGTGAGTTTGC
GGCGCACTTGGATAAATTGAAGAAGGAGTGA
Antitoxin
Download Length: 101 a.a. Molecular weight: 11006.73 Da Isoelectric Point: 7.2036
>AT89831 WP_000124640.1 NZ_CP025144:48385-48687 [Klebsiella pneumoniae]
MARTLDQMLATEKPEVVAKAQKAATEMLLNIHLAELRDRMNLTQGEIAASLGVRQPTVSEMEKPGRDLKLSSIKRYVEAS
GGKLRLDVELPDGTHYGFAV
MARTLDQMLATEKPEVVAKAQKAATEMLLNIHLAELRDRMNLTQGEIAASLGVRQPTVSEMEKPGRDLKLSSIKRYVEAS
GGKLRLDVELPDGTHYGFAV
Download Length: 303 bp
>AT89831 NZ_CP025144:48385-48687 [Klebsiella pneumoniae]
ATGGCAAGAACTCTTGACCAAATGCTGGCAACAGAAAAGCCTGAGGTTGTTGCCAAAGCACAGAAAGCGGCCACTGAGAT
GTTACTGAACATCCACTTGGCAGAGCTTCGTGATCGCATGAACCTTACCCAGGGGGAAATTGCTGCATCTCTGGGTGTGA
GACAGCCGACAGTCTCCGAGATGGAAAAACCTGGACGAGATCTCAAGCTGTCGTCCATTAAGCGGTACGTTGAGGCCTCC
GGTGGCAAGCTACGCCTCGATGTTGAACTTCCGGACGGCACCCACTACGGCTTTGCCGTTTAA
ATGGCAAGAACTCTTGACCAAATGCTGGCAACAGAAAAGCCTGAGGTTGTTGCCAAAGCACAGAAAGCGGCCACTGAGAT
GTTACTGAACATCCACTTGGCAGAGCTTCGTGATCGCATGAACCTTACCCAGGGGGAAATTGCTGCATCTCTGGGTGTGA
GACAGCCGACAGTCTCCGAGATGGAAAAACCTGGACGAGATCTCAAGCTGTCGTCCATTAAGCGGTACGTTGAGGCCTCC
GGTGGCAAGCTACGCCTCGATGTTGAACTTCCGGACGGCACCCACTACGGCTTTGCCGTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|