Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1697832..1698468 Replicon chromosome
Accession NZ_CP025120
Organism Kangiella profundi strain FT102

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag CW740_RS07925 Protein ID WP_106647009.1
Coordinates 1698175..1698468 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag CW740_RS07920 Protein ID WP_106647008.1
Coordinates 1697832..1698158 (-) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CW740_RS07900 1693824..1694390 - 567 WP_106647005.1 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase -
CW740_RS07905 1694462..1696300 - 1839 WP_106647006.1 excinuclease ABC subunit UvrC -
CW740_RS07910 1696323..1696961 - 639 WP_106648088.1 UvrY/SirA/GacA family response regulator transcription factor -
CW740_RS07915 1697067..1697600 + 534 WP_106647007.1 hypothetical protein -
CW740_RS07920 1697832..1698158 - 327 WP_106647008.1 HigA family addiction module antidote protein Antitoxin
CW740_RS07925 1698175..1698468 - 294 WP_106647009.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CW740_RS07930 1698846..1700927 - 2082 WP_106647010.1 TonB-dependent receptor -
CW740_RS07935 1701032..1702849 - 1818 WP_106647011.1 DUF262 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-70)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11440.05 Da        Isoelectric Point: 7.8739

>T89787 WP_106647009.1 NZ_CP025120:c1698468-1698175 [Kangiella profundi]
MAITFRDDWLEAFYEDDISHRKIPKNIQNALYRKLQIIDAATEEADLRVPPGNCFEHLKGKLKGWCSIRVNKQYRLIFRW
VDGAGENTYLDPHVYRG

Download         Length: 294 bp

>T89787 NZ_CP025120:c1698468-1698175 [Kangiella profundi]
ATGGCAATTACGTTCAGGGATGATTGGCTAGAAGCTTTTTATGAAGACGATATTTCCCACCGGAAAATCCCTAAAAATAT
TCAAAATGCTTTATATAGAAAGCTACAAATCATCGATGCAGCAACTGAAGAAGCGGATCTGAGAGTACCTCCTGGTAACT
GTTTCGAACATTTAAAAGGTAAGTTAAAAGGTTGGTGCTCCATTCGAGTTAATAAGCAATATCGGCTTATTTTTAGATGG
GTCGATGGAGCTGGAGAAAATACTTATCTAGACCCTCATGTATATAGGGGCTAG

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12220.10 Da        Isoelectric Point: 9.1287

>AT89787 WP_106647008.1 NZ_CP025120:c1698158-1697832 [Kangiella profundi]
MRNTKRRPVTVGQMLVSEFMEPMGIEINELAEAMGVHRNTLSRIVNDKGSLTAPMAIKLAAALGNTPEFWLNIQHSVELW
DVRHKAYADEARNVKRVKSHTEPHQTVC

Download         Length: 327 bp

>AT89787 NZ_CP025120:c1698158-1697832 [Kangiella profundi]
ATGAGAAATACAAAACGACGCCCAGTGACGGTTGGTCAAATGTTGGTGAGTGAGTTTATGGAGCCAATGGGTATTGAAAT
TAATGAATTGGCTGAGGCTATGGGTGTTCACCGTAATACTTTAAGTCGAATCGTTAATGATAAGGGTTCCTTGACTGCAC
CGATGGCGATTAAGCTGGCGGCCGCTTTAGGGAATACCCCTGAGTTCTGGCTCAATATTCAGCATTCCGTTGAGTTGTGG
GATGTTCGCCATAAGGCTTATGCAGATGAAGCCAGAAATGTTAAAAGAGTAAAGTCCCATACCGAACCTCATCAAACTGT
TTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References