89725

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 784892..785404 Replicon chromosome
Accession NZ_CP025076
Organism Streptococcus pneumoniae strain BHN97x

Toxin (Protein)


Gene name yoeB Uniprot ID Q8DNR3
Locus tag CWI64_RS04090 Protein ID WP_000924721.1
Coordinates 784892..785146 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID K0ZY22
Locus tag CWI64_RS04095 Protein ID WP_000388572.1
Coordinates 785150..785404 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CWI64_RS04070 780219..780533 - 315 WP_000979235.1 DNA-directed RNA polymerase subunit omega -
CWI64_RS04075 780558..781184 - 627 WP_000775037.1 guanylate kinase -
CWI64_RS04080 781314..782927 - 1614 WP_000404938.1 ribonuclease Y -
CWI64_RS04085 783122..784519 + 1398 WP_001812180.1 ISNCY family transposase -
CWI64_RS04090 784892..785146 - 255 WP_000924721.1 Txe/YoeB family addiction module toxin Toxin
CWI64_RS04095 785150..785404 - 255 WP_000388572.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CWI64_RS04100 785642..786739 - 1098 WP_000156334.1 nucleotidyltransferase -
CWI64_RS04105 786749..787489 - 741 WP_000257066.1 class I SAM-dependent methyltransferase -
CWI64_RS04110 787809..788162 - 354 WP_001003001.1 ribosome silencing factor -
CWI64_RS04115 788175..788675 - 501 WP_000844719.1 cysteine hydrolase -
CWI64_RS04120 788676..789269 - 594 WP_000121673.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) YqeK -
CWI64_RS04125 789269..789898 - 630 WP_000151309.1 nicotinate-nucleotide adenylyltransferase -
CWI64_RS04130 789950..790261 - 312 WP_000060169.1 ribosome assembly RNA-binding protein YhbY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 783122..784519 1397


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-75)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10115.55 Da        Isoelectric Point: 7.9716

>T89725 WP_000924721.1 NZ_CP025076:c785146-784892 [Streptococcus pneumoniae]
MLLKFTEDAWADYCYWQNQDKKTLKRINKLIKDIQRDPFTGIGKPEPLKYDYQGAWSRRIDAENRLIYMMDGDSVAFLSF
KDHY

Download         Length: 255 bp

>T89725 NZ_CP025076:c785146-784892 [Streptococcus pneumoniae]
ATGCTACTCAAGTTTACAGAAGATGCCTGGGCAGATTATTGCTACTGGCAAAACCAAGATAAAAAAACACTAAAAAGAAT
CAATAAATTAATCAAGGATATTCAACGCGATCCATTTACAGGAATAGGAAAACCAGAGCCACTCAAATATGATTACCAAG
GAGCCTGGTCACGGCGTATTGATGCAGAAAATCGCTTGATTTATATGATGGATGGAGATAGCGTGGCTTTCTTGTCCTTT
AAAGATCATTACTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9706.00 Da        Isoelectric Point: 4.8430

>AT89725 WP_000388572.1 NZ_CP025076:c785404-785150 [Streptococcus pneumoniae]
MEAVLYSTFRNHLKDYMKKVNDEFEPLTVVNKNPDEDIVVLSKSEWDSIQETLRIAQNKELSDKVLRGMAQVRAGSTQVH
VIEE

Download         Length: 255 bp

>AT89725 NZ_CP025076:c785404-785150 [Streptococcus pneumoniae]
ATGGAAGCAGTCCTTTACTCAACATTCCGAAATCATTTAAAGGACTACATGAAGAAGGTAAATGATGAATTTGAGCCTTT
GACGGTGGTCAATAAAAATCCAGATGAGGACATTGTAGTTCTTTCAAAGAGCGAATGGGACAGTATTCAGGAAACCCTGA
GAATCGCCCAAAATAAGGAGTTATCAGACAAGGTTTTGCGAGGAATGGCTCAAGTCCGTGCTGGAAGCACTCAGGTCCAT
GTGATTGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B7LEN4

Antitoxin

Source ID Structure
AlphaFold DB K0ZY22

References