Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 1405275..1405975 Replicon chromosome
Accession NZ_CP025069
Organism Bordetella bronchiseptica strain I124

Toxin (Protein)


Gene name mqsR Uniprot ID A0A807DZC1
Locus tag CWR61_RS06800 Protein ID WP_068925399.1
Coordinates 1405275..1405571 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID Q7VY40
Locus tag CWR61_RS06805 Protein ID WP_003809516.1
Coordinates 1405574..1405975 (+) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CWR61_RS06775 1400279..1401409 - 1131 WP_068925397.1 helix-turn-helix transcriptional regulator -
CWR61_RS06780 1401657..1402199 + 543 WP_015064289.1 MOSC domain-containing protein -
CWR61_RS06785 1402375..1403439 + 1065 WP_015064288.1 fructose-bisphosphate aldolase class II -
CWR61_RS06790 1403524..1403970 - 447 WP_033464956.1 GFA family protein -
CWR61_RS06795 1404198..1405079 + 882 WP_033464953.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
CWR61_RS06800 1405275..1405571 + 297 WP_068925399.1 type II toxin-antitoxin system MqsR family toxin Toxin
CWR61_RS06805 1405574..1405975 + 402 WP_003809516.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
CWR61_RS06810 1405995..1406231 + 237 WP_003809519.1 hypothetical protein -
CWR61_RS06815 1406239..1406718 + 480 WP_003809523.1 disulfide bond formation protein B -
CWR61_RS06820 1406866..1407381 + 516 WP_033464945.1 5-(carboxyamino)imidazole ribonucleotide mutase -
CWR61_RS06825 1407384..1408574 + 1191 WP_068925401.1 5-(carboxyamino)imidazole ribonucleotide synthase -
CWR61_RS06830 1408593..1409630 + 1038 WP_068925403.1 threonylcarbamoyl-AMP synthase -
CWR61_RS06835 1409766..1410788 + 1023 WP_068925405.1 amino acid ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(2-97)

Antitoxin

Antitoxin MqsA/HigA-2

(1-131)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 10592.55 Da        Isoelectric Point: 8.5344

>T89702 WP_068925399.1 NZ_CP025069:1405275-1405571 [Bordetella bronchiseptica]
MEKGTPHCKLPALKALVHAGKVRATFSALSGAAALGLDFSAMVEIVLALTPRDFHKSMTTHADHRIWQDVYCPVTAMGAV
YLKLTVLDGVLIVSFKEL

Download         Length: 297 bp

>T89702 NZ_CP025069:1405275-1405571 [Bordetella bronchiseptica]
ATGGAAAAGGGAACACCGCACTGCAAGCTGCCGGCGCTCAAGGCGCTGGTCCATGCAGGCAAGGTCCGAGCCACGTTTTC
CGCCTTGTCCGGCGCGGCGGCGCTGGGGCTGGATTTCAGCGCCATGGTCGAAATCGTGCTTGCACTGACACCGCGGGATT
TCCACAAAAGCATGACTACCCATGCCGACCATCGCATTTGGCAGGACGTCTATTGCCCAGTGACAGCGATGGGCGCCGTC
TACCTGAAGCTGACGGTCCTCGACGGCGTGCTGATCGTGTCGTTCAAGGAGTTGTGA

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14528.70 Da        Isoelectric Point: 8.5005

>AT89702 WP_003809516.1 NZ_CP025069:1405574-1405975 [Bordetella bronchiseptica]
MKCPVCGAAALARDTRDVPYSYKGETITIAAVTGDWCPACGENVLDGAESARVSEAMLAFNRLVNARRVDPGFIVRVRRK
LGLDQREAAALFGGGTNAFSRYENGKTRPPLALVKLLRLLDRHPELLEEVRAD

Download         Length: 402 bp

>AT89702 NZ_CP025069:1405574-1405975 [Bordetella bronchiseptica]
ATGAAGTGTCCCGTATGCGGAGCGGCCGCGCTGGCGCGTGATACTCGCGATGTGCCCTATAGCTACAAGGGCGAGACCAT
CACCATTGCGGCGGTGACGGGCGACTGGTGTCCGGCATGCGGCGAGAACGTGCTCGATGGCGCCGAATCGGCGCGGGTGA
GCGAGGCCATGCTGGCTTTCAACCGCCTGGTCAACGCCCGCCGCGTCGACCCCGGGTTCATCGTGCGGGTGCGCAGGAAG
CTGGGGTTGGACCAGCGCGAAGCCGCGGCGCTGTTCGGCGGCGGCACCAATGCGTTCTCGCGTTACGAGAACGGCAAGAC
GCGCCCGCCGCTGGCGCTGGTGAAGCTGCTCAGGCTGCTGGATCGCCATCCGGAGCTGCTGGAGGAAGTCCGCGCGGATT
GA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A807DZC1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3LKS6

References