89653

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 5435615..5436210 Replicon chromosome
Accession NZ_CP025049
Organism Pseudomonas aeruginosa strain PB369

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag CWI25_RS26380 Protein ID WP_003113526.1
Coordinates 5435932..5436210 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag CWI25_RS26375 Protein ID WP_003133769.1
Coordinates 5435615..5435920 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CWI25_RS26340 5431181..5431471 - 291 WP_023083237.1 DUF5447 family protein -
CWI25_RS26345 5431647..5431919 - 273 WP_004352675.1 hypothetical protein -
CWI25_RS26350 5432032..5432304 + 273 WP_034021304.1 hypothetical protein -
CWI25_RS26355 5432360..5432695 + 336 WP_025921265.1 hypothetical protein -
CWI25_RS26360 5432856..5434232 + 1377 WP_071534372.1 DUF3696 domain-containing protein -
CWI25_RS26365 5434229..5434711 + 483 WP_071534371.1 hypothetical protein -
CWI25_RS26370 5434872..5435279 - 408 WP_052151012.1 hypothetical protein -
CWI25_RS26375 5435615..5435920 - 306 WP_003133769.1 HigA family addiction module antidote protein Antitoxin
CWI25_RS26380 5435932..5436210 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CWI25_RS26390 5436539..5438767 + 2229 WP_021264080.1 TonB-dependent receptor -
CWI25_RS26395 5438838..5439485 - 648 WP_003095021.1 carbonate dehydratase -
CWI25_RS26400 5439547..5440785 - 1239 WP_043085810.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-82)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T89653 WP_003113526.1 NZ_CP025049:c5436210-5435932 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

>T89653 NZ_CP025049:c5436210-5435932 [Pseudomonas aeruginosa]
CTGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTACGGAGCTTCGAGACTTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATAGCATCAGGATCAACGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11214.73 Da        Isoelectric Point: 4.6081

>AT89653 WP_003133769.1 NZ_CP025049:c5435920-5435615 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGEQIEHEIEPLLAHG

Download         Length: 306 bp

>AT89653 NZ_CP025049:c5435920-5435615 [Pseudomonas aeruginosa]
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTGGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAACGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTATTCGTTAGCA
ACTGCTTATGCGGCGAATGGCGAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCACGGATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure

References