Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 2218737..2219256 Replicon chromosome
Accession NZ_CP025043
Organism Streptococcus suis strain AH681

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0Z8N5V4
Locus tag CWI26_RS10915 Protein ID WP_024419186.1
Coordinates 2218737..2218994 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A075STV3
Locus tag CWI26_RS10920 Protein ID WP_029693774.1
Coordinates 2218996..2219256 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CWI26_RS10900 2215369..2217099 - 1731 WP_024379287.1 membrane protein -
CWI26_RS10905 2217302..2218174 - 873 WP_024378763.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
CWI26_RS10910 2218193..2218723 - 531 WP_024419185.1 DUF1697 domain-containing protein -
CWI26_RS10915 2218737..2218994 - 258 WP_024419186.1 Txe/YoeB family addiction module toxin Toxin
CWI26_RS10920 2218996..2219256 - 261 WP_029693774.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CWI26_RS10925 2219332..2219787 - 456 WP_099870748.1 8-oxo-dGTP diphosphatase -
CWI26_RS10930 2219796..2220125 - 330 WP_029187570.1 type II toxin-antitoxin system RelE/ParE family toxin -
CWI26_RS10935 2220115..2220402 - 288 WP_002940311.1 hypothetical protein -
CWI26_RS10940 2220500..2220868 - 369 WP_099875905.1 hypothetical protein -
CWI26_RS10945 2220861..2221430 - 570 WP_099875940.1 ribonuclease M5 -
CWI26_RS10950 2221414..2222196 - 783 WP_100881781.1 TatD family hydrolase -
CWI26_RS10955 2222304..2222441 - 138 WP_002939016.1 50S ribosomal protein L34 -
CWI26_RS10960 2222609..2223604 - 996 WP_044765292.1 protein jag -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-75)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10305.80 Da        Isoelectric Point: 7.1609

>T89586 WP_024419186.1 NZ_CP025043:c2218994-2218737 [Streptococcus suis]
MGIHFTDDAWEDYLYWQGQDKKTLKRINKIIKDMQRHLFEGIAKPEPLKYDYQGAWSRRIDAENRLIYMVESDRLCILSL
KDYYG

Download         Length: 258 bp

>T89586 NZ_CP025043:c2218994-2218737 [Streptococcus suis]
ATGGGAATTCATTTTACAGACGACGCCTGGGAAGACTATCTTTATTGGCAGGGTCAGGATAAGAAAACACTGAAGAGAAT
CAATAAGATTATCAAGGATATGCAACGACATCTTTTTGAAGGTATTGCCAAGCCAGAACCTTTGAAGTATGATTATCAGG
GTGCCTGGTCAAGAAGGATTGATGCGGAGAATCGGTTGATTTATATGGTGGAATCCGATCGGTTGTGCATCCTGTCGCTA
AAGGACTATTATGGGTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9920.27 Da        Isoelectric Point: 5.1255

>AT89586 WP_029693774.1 NZ_CP025043:c2219256-2218996 [Streptococcus suis]
MEAIVYSHFRNHLKDYMKKVNDEFEPLVVVNKNPEEDIVVLSKSEWDSLQETLAVARNAYLSQKVLRGMAQVKAGQTQER
NLIEAD

Download         Length: 261 bp

>AT89586 NZ_CP025043:c2219256-2218996 [Streptococcus suis]
ATGGAAGCTATTGTATATTCCCATTTTCGAAATCACTTAAAGGACTACATGAAAAAGGTCAATGACGAGTTTGAGCCTTT
GGTCGTGGTTAATAAAAATCCAGAGGAAGATATTGTTGTACTGTCAAAGAGTGAGTGGGATAGCTTACAAGAAACCCTTG
CTGTTGCTCGGAACGCTTATCTGTCTCAAAAAGTTTTGCGTGGTATGGCTCAAGTCAAAGCGGGACAAACCCAAGAACGC
AATCTGATAGAGGCAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8N5V4

Antitoxin

Source ID Structure
AlphaFold DB A0A075STV3

References