Detailed information of TA system TA089542

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-sprA1AS/-
• Location: 993249..993397
• Replicon: chromosome
• Accession: NZ_CP025031
• Organism: Staphylococcus haemolyticus strain SGAir0252

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: -
• Locus tag: CWR44_RS04830
• Protein ID: WP_011276848.1
• Coordinates: 993302..993397 (-)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	993249..993284 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CWR44_RS04805	988533..990290	-	1758	WP_001096374.1	beta-lactam sensor/signal transducer BlaR1	-
CWR44_RS04810	990397..991242	+	846	WP_000733283.1	BlaZ family penicillin-hydrolyzing class A beta-lactamase PC1	-
CWR44_RS04820	991601..992203	-	603	WP_011276850.1	hypothetical protein	-
CWR44_RS04825	992449..993108	-	660	WP_011276849.1	nucleotidyltransferase	-
-	993249..993284	-	36	-	-	Antitoxin
CWR44_RS04830	993302..993397	-	96	WP_011276848.1	type I toxin-antitoxin system Fst family toxin	Toxin
CWR44_RS13300	993592..993738	-	147	WP_000668388.1	hypothetical protein	-
CWR44_RS04835	993862..994166	-	305	Protein_949	hypothetical protein	-
CWR44_RS04840	994305..994688	-	384	WP_011276846.1	effector binding domain-containing protein	-
CWR44_RS04845	994928..995458	-	531	WP_011276845.1	N-acetyltransferase	-
CWR44_RS13305	996062..996319	-	258	Protein_952	replication initiation protein	-
CWR44_RS04860	997012..997329	+	318	Protein_953	IS200/IS605-like element ISSep3 family transposase	-
CWR44_RS04865	997437..997670	-	234	WP_016931184.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	SCCmec	aac(6')-aph(2'') / blaZ	clpC / tufA / clpP	961943..1495954	534011
	-	flank	IS/Tn	-	-	997012..997332	320

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3623.38 Da
• Isoelectric Point: 9.5124

>T89542 WP_011276848.1 NZ_CP025031:c993397-993302 [Staphylococcus haemolyticus]
MLEILVHITTTVISGCIIALFTHWLRNRKDK

Nucleotide

• Length: 96 bp

>T89542 NZ_CP025031:c993397-993302 [Staphylococcus haemolyticus]
ATGTTGGAAATCCTTGTTCACATCACGACCACAGTCATCAGTGGTTGTATTATTGCGTTATTTACGCATTGGCTGCGTAA
TCGCAAAGACAAATAG

Antitoxin

Nucleotide

• Length: 36 bp

>AT89542 NZ_CP025031:c993284-993249 [Staphylococcus haemolyticus]
TACAACAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin