Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2395699..2396216 Replicon chromosome
Accession NZ_CP025023
Organism Staphylococcus argenteus strain XNO106

Toxin (Protein)


Gene name yoeB Uniprot ID A0A7U7PWL3
Locus tag CKO49_RS11825 Protein ID WP_031787172.1
Coordinates 2395699..2395965 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A7U7PWU0
Locus tag CKO49_RS11830 Protein ID WP_031787173.1
Coordinates 2395965..2396216 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CKO49_RS11800 2391129..2391665 - 537 WP_031787169.1 GNAT family N-acetyltransferase -
CKO49_RS11805 2391898..2392722 - 825 WP_000572040.1 formate/nitrite transporter family protein -
CKO49_RS11810 2392939..2393124 - 186 WP_000230291.1 hypothetical protein -
CKO49_RS11815 2393208..2393675 - 468 WP_031787170.1 SRPBCC domain-containing protein -
CKO49_RS11820 2393858..2395402 - 1545 WP_031787171.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
CKO49_RS11825 2395699..2395965 - 267 WP_031787172.1 Txe/YoeB family addiction module toxin Toxin
CKO49_RS11830 2395965..2396216 - 252 WP_031787173.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CKO49_RS11835 2396488..2397087 - 600 WP_000162802.1 DsbA family protein -
CKO49_RS11840 2397107..2397469 - 363 WP_031787174.1 DUF4467 domain-containing protein -
CKO49_RS11845 2397723..2398973 + 1251 WP_031787175.1 aminoacyltransferase -
CKO49_RS11850 2399068..2399799 - 732 WP_000615469.1 amino acid ABC transporter ATP-binding protein -
CKO49_RS11855 2399796..2400515 - 720 WP_000479573.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10511.99 Da        Isoelectric Point: 9.7791

>T89526 WP_031787172.1 NZ_CP025023:c2395965-2395699 [Staphylococcus argenteus]
MARLNITFSPQAFEDYEYFQQNDKKMVKKINELLKSIDRNGALQGIGKPEKLKSNLFGYYSRRINHEHRLVYTVDDNHIK
IASCRYHY

Download         Length: 267 bp

>T89526 NZ_CP025023:c2395965-2395699 [Staphylococcus argenteus]
ATGGCTAGGTTAAACATTACGTTCTCGCCTCAGGCATTTGAAGATTATGAGTATTTTCAGCAGAACGATAAAAAAATGGT
AAAGAAGATTAATGAGTTACTTAAAAGCATTGATAGAAATGGTGCATTGCAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATTTATTTGGCTATTATAGTAGACGTATCAATCACGAACATAGGTTGGTTTATACAGTTGACGATAATCACATAAAA
ATAGCATCCTGTAGATACCATTATTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9395.56 Da        Isoelectric Point: 4.3558

>AT89526 WP_031787173.1 NZ_CP025023:c2396216-2395965 [Staphylococcus argenteus]
MIVKNYSYARQNLKTLMTKVNDDSDVVTVTSTDDKNVVIMSEADYNSIIETLYLQQNPNNAEHLAQSIADLERGKMVTKE
IDV

Download         Length: 252 bp

>AT89526 NZ_CP025023:c2396216-2395965 [Staphylococcus argenteus]
ATGATTGTAAAAAACTATTCTTACGCTAGACAGAATTTAAAGACGCTTATGACAAAGGTAAATGACGATAGTGATGTGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATTATGTCAGAAGCAGATTATAATTCTATAATTGAAACCCTTTACC
TTCAACAGAATCCAAATAATGCTGAACACTTAGCCCAATCAATTGCTGACTTAGAACGAGGCAAAATGGTAACGAAAGAA
ATAGATGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7PWL3

Antitoxin

Source ID Structure
AlphaFold DB A0A7U7PWU0

References