Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1734372..1734947 Replicon chromosome
Accession NZ_CP025000
Organism Idiomarina sp. X4

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag CWC33_RS08265 Protein ID WP_100691553.1
Coordinates 1734669..1734947 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag CWC33_RS08260 Protein ID WP_100691552.1
Coordinates 1734372..1734659 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CWC33_RS08240 1730284..1731981 - 1698 WP_100691549.1 DUF262 domain-containing HNH endonuclease family protein -
CWC33_RS08245 1732314..1732634 + 321 WP_100691550.1 helix-turn-helix transcriptional regulator -
CWC33_RS08250 1732631..1733956 + 1326 WP_100691551.1 type II toxin-antitoxin system HipA family toxin -
CWC33_RS08255 1734003..1734353 - 351 WP_198511816.1 VOC family protein -
CWC33_RS08260 1734372..1734659 - 288 WP_100691552.1 HigA family addiction module antidote protein Antitoxin
CWC33_RS08265 1734669..1734947 - 279 WP_100691553.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CWC33_RS08270 1735029..1735904 - 876 WP_100691554.1 DNA ligase -
CWC33_RS08275 1736098..1736496 + 399 WP_100691555.1 DUF393 domain-containing protein -
CWC33_RS08280 1736536..1736940 + 405 WP_129497108.1 catalase -
CWC33_RS08285 1736957..1737154 + 198 Protein_1605 cytochrome b/b6 domain-containing protein -
CWC33_RS08290 1737280..1737477 + 198 WP_088767576.1 hypothetical protein -
CWC33_RS08295 1737492..1737791 + 300 WP_088767577.1 Rho termination factor N-terminal domain-containing protein -
CWC33_RS08300 1737858..1738565 + 708 WP_100691556.1 NERD domain-containing protein -
CWC33_RS08305 1738644..1739447 + 804 WP_100691557.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(3-86)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10345.75 Da        Isoelectric Point: 10.7124

>T89448 WP_100691553.1 NZ_CP025000:c1734947-1734669 [Idiomarina sp. X4]
VIRNFKHKGLAKFFRFGSAAGIQASHAKRLRLILGRLNAASGTKDMDLPGLRLHELSGNRSGIWSVTVSGNWRVTFRFED
GDAEIVNYEDYH

Download         Length: 279 bp

>T89448 NZ_CP025000:c1734947-1734669 [Idiomarina sp. X4]
GTGATCCGAAACTTCAAGCACAAAGGTTTGGCTAAGTTTTTCAGGTTCGGTAGCGCCGCAGGGATTCAGGCCAGCCACGC
AAAGAGGCTTCGGCTTATTCTCGGTAGGTTGAATGCGGCATCTGGCACAAAAGATATGGATTTGCCAGGTCTTCGACTTC
ATGAGCTCTCCGGTAACCGCTCTGGAATTTGGTCAGTGACGGTCAGTGGAAACTGGCGCGTGACCTTCCGATTTGAGGAT
GGAGATGCAGAGATAGTAAATTATGAAGATTATCACTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10385.03 Da        Isoelectric Point: 8.0936

>AT89448 WP_100691552.1 NZ_CP025000:c1734659-1734372 [Idiomarina sp. X4]
MLMHNPPHPGEVVRELCLEPLGLSVTAAADALGVSRKTLSAVLNGKAGISPEMAIRLSIAFNTSAESWLNQQSQYELWHA
EQHRKELKVKKLVAA

Download         Length: 288 bp

>AT89448 NZ_CP025000:c1734659-1734372 [Idiomarina sp. X4]
ATGCTAATGCACAACCCCCCCCACCCTGGCGAAGTTGTACGAGAGCTTTGTCTCGAGCCTCTTGGCTTATCTGTAACCGC
TGCAGCGGACGCTTTGGGCGTAAGCCGGAAAACGTTAAGTGCTGTTCTGAACGGCAAGGCTGGTATTAGCCCTGAAATGG
CTATCAGACTATCAATCGCATTTAATACTTCAGCGGAAAGCTGGCTAAACCAGCAGTCCCAGTATGAACTCTGGCATGCC
GAGCAACATCGTAAAGAACTCAAGGTTAAGAAGCTCGTTGCCGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References