Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1981880..1982403 Replicon chromosome
Accession NZ_CP024998
Organism Staphylococcus aureus strain 55-99-44

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag CU118_RS10285 Protein ID WP_054189905.1
Coordinates 1981880..1982146 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag CU118_RS10290 Protein ID WP_020977565.1
Coordinates 1982146..1982403 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CU118_RS10265 1977088..1978275 - 1188 WP_054189907.1 MFS transporter -
CU118_RS10270 1978669..1979445 - 777 WP_000072151.1 iron export ABC transporter permease subunit FetB -
CU118_RS10275 1979438..1980100 - 663 WP_025786559.1 ATP-binding cassette domain-containing protein -
CU118_RS10280 1980450..1981526 - 1077 WP_100793838.1 M42 family metallopeptidase -
CU118_RS10285 1981880..1982146 - 267 WP_054189905.1 Txe/YoeB family addiction module toxin Toxin
CU118_RS10290 1982146..1982403 - 258 WP_020977565.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CU118_RS10300 1982763..1983218 + 456 WP_000732082.1 DUF1307 domain-containing protein -
CU118_RS10305 1983386..1984963 - 1578 WP_054189904.1 FMN-binding glutamate synthase family protein -
CU118_RS10310 1985158..1985907 + 750 WP_054189903.1 hypothetical protein -
CU118_RS10315 1986131..1987324 - 1194 WP_006191034.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10587.19 Da        Isoelectric Point: 10.1603

>T89441 WP_054189905.1 NZ_CP024998:c1982146-1981880 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKITHPYLKKTFIEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRGVYTIDDRNKVVLI
LSAWSHYD

Download         Length: 267 bp

>T89441 NZ_CP024998:c1982146-1981880 [Staphylococcus aureus]
ATGAGCAATTATACGGTTAAGATTAAAAATTCGGCGAAATCAGATTTAAAGAAAATAACACATCCTTATTTAAAGAAGAC
ATTTATAGAAATTGTTGAGACTTTAAAAAATGATCCTTATAAAATAACACAATCCTTTGAAAAATTAGAACCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGGCGTCTATACCATAGATGATCGAAATAAAGTAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9796.79 Da        Isoelectric Point: 4.3304

>AT89441 WP_020977565.1 NZ_CP024998:c1982403-1982146 [Staphylococcus aureus]
MIITSPTEARKHFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT89441 NZ_CP024998:c1982403-1982146 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAGCATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References