Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 1950565..1950749 Replicon chromosome
Accession NZ_CP024998
Organism Staphylococcus aureus strain 55-99-44

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2K4AFL5
Locus tag CU118_RS10130 Protein ID WP_000482651.1
Coordinates 1950642..1950749 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 1950565..1950625 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CU118_RS10100 1946109..1947224 - 1116 WP_054189927.1 pyridoxal phosphate-dependent aminotransferase family protein -
CU118_RS10105 1947202..1948209 - 1008 WP_001046647.1 biotin synthase BioB -
CU118_RS10110 1948211..1949569 - 1359 WP_054189926.1 adenosylmethionine--8-amino-7-oxononanoate transaminase -
CU118_RS10115 1949547..1950233 - 687 WP_054189925.1 dethiobiotin synthase -
CU118_RS10120 1950288..1950455 - 168 Protein_1887 hypothetical protein -
- 1950565..1950625 + 61 - - Antitoxin
CU118_RS10130 1950642..1950749 - 108 WP_000482651.1 type I toxin-antitoxin system Fst family toxin Toxin
CU118_RS10135 1950883..1951269 - 387 WP_054189924.1 flippase GtxA -
CU118_RS10140 1951537..1952679 + 1143 WP_054189923.1 glycerate kinase -
CU118_RS10145 1952739..1953392 + 654 WP_054189922.1 hypothetical protein -
CU118_RS10150 1953574..1954785 + 1212 WP_054189921.1 multidrug effflux MFS transporter -
CU118_RS10155 1954909..1955382 - 474 WP_054189920.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 3984.75 Da        Isoelectric Point: 11.0582

>T89439 WP_000482651.1 NZ_CP024998:c1950749-1950642 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRSNKKGDK

Download         Length: 108 bp

>T89439 NZ_CP024998:c1950749-1950642 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTATAAGTGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAGCAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT89439 NZ_CP024998:1950565-1950625 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTATTGCCGTAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K4AFL5

Antitoxin

Download structure file

References