Detailed information of TA system TA089438

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 1929648..1930165
• Replicon: chromosome
• Accession: NZ_CP024998
• Organism: Staphylococcus aureus strain 55-99-44

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: CU118_RS09990
• Protein ID: WP_054189942.1
• Coordinates: 1929648..1929914 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: CU118_RS09995
• Protein ID: WP_054189941.1
• Coordinates: 1929914..1930165 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CU118_RS09960	1924853..1925389	-	537	WP_054189946.1	GNAT family N-acetyltransferase	-
CU118_RS09970	1925858..1926682	-	825	WP_000594640.1	formate/nitrite transporter family protein	-
CU118_RS09975	1926885..1927067	-	183	WP_054189945.1	hypothetical protein	-
CU118_RS09980	1927154..1927621	-	468	WP_054189944.1	SRPBCC domain-containing protein	-
CU118_RS09985	1927807..1929354	-	1548	WP_054189943.1	zinc ABC transporter substrate-binding lipoprotein AdcA	-
CU118_RS09990	1929648..1929914	-	267	WP_054189942.1	Txe/YoeB family addiction module toxin	Toxin
CU118_RS09995	1929914..1930165	-	252	WP_054189941.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
CU118_RS10000	1930330..1930431	-	102	Protein_1865	hypothetical protein	-
CU118_RS10005	1930438..1931037	-	600	WP_054189940.1	DsbA family protein	-
CU118_RS10010	1931056..1931418	-	363	WP_054189939.1	DUF4467 domain-containing protein	-
CU118_RS10015	1931674..1932924	+	1251	WP_054189938.1	FemA/FemB family glycyltransferase FmhA	-
CU118_RS10020	1933019..1933750	-	732	WP_054189937.1	amino acid ABC transporter ATP-binding protein	-
CU118_RS10025	1933747..1934466	-	720	WP_054189936.1	amino acid ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (8-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10393.94 Da
• Isoelectric Point: 10.0573

>T89438 WP_054189942.1 NZ_CP024998:c1929914-1929648 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMALKINELLKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Nucleotide

• Length: 267 bp

>T89438 NZ_CP024998:c1929914-1929648 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTCTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGC
ATTGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGCGCATTGAAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGACTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9463.69 Da
• Isoelectric Point: 4.3407

>AT89438 WP_054189941.1 NZ_CP024998:c1930165-1929914 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTIMKD
IDV

Nucleotide

• Length: 252 bp

>AT89438 NZ_CP024998:c1930165-1929914 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTAGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAATGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAACAACGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGCAAAACTATAATGAAAGAT
ATAGATGTATAA