Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1929648..1930165 Replicon chromosome
Accession NZ_CP024998
Organism Staphylococcus aureus strain 55-99-44

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag CU118_RS09990 Protein ID WP_054189942.1
Coordinates 1929648..1929914 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag CU118_RS09995 Protein ID WP_054189941.1
Coordinates 1929914..1930165 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CU118_RS09960 1924853..1925389 - 537 WP_054189946.1 GNAT family N-acetyltransferase -
CU118_RS09970 1925858..1926682 - 825 WP_000594640.1 formate/nitrite transporter family protein -
CU118_RS09975 1926885..1927067 - 183 WP_054189945.1 hypothetical protein -
CU118_RS09980 1927154..1927621 - 468 WP_054189944.1 SRPBCC domain-containing protein -
CU118_RS09985 1927807..1929354 - 1548 WP_054189943.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
CU118_RS09990 1929648..1929914 - 267 WP_054189942.1 Txe/YoeB family addiction module toxin Toxin
CU118_RS09995 1929914..1930165 - 252 WP_054189941.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CU118_RS10000 1930330..1930431 - 102 Protein_1865 hypothetical protein -
CU118_RS10005 1930438..1931037 - 600 WP_054189940.1 DsbA family protein -
CU118_RS10010 1931056..1931418 - 363 WP_054189939.1 DUF4467 domain-containing protein -
CU118_RS10015 1931674..1932924 + 1251 WP_054189938.1 FemA/FemB family glycyltransferase FmhA -
CU118_RS10020 1933019..1933750 - 732 WP_054189937.1 amino acid ABC transporter ATP-binding protein -
CU118_RS10025 1933747..1934466 - 720 WP_054189936.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10393.94 Da        Isoelectric Point: 10.0573

>T89438 WP_054189942.1 NZ_CP024998:c1929914-1929648 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMALKINELLKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T89438 NZ_CP024998:c1929914-1929648 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTCTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGC
ATTGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGCGCATTGAAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGACTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9463.69 Da        Isoelectric Point: 4.3407

>AT89438 WP_054189941.1 NZ_CP024998:c1930165-1929914 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTIMKD
IDV

Download         Length: 252 bp

>AT89438 NZ_CP024998:c1930165-1929914 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTAGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAATGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAACAACGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGCAAAACTATAATGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References