Detailed information of TA system TA089433

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-MW1433/-
• Location: 1351426..1351733
• Replicon: chromosome
• Accession: NZ_CP024998
• Organism: Staphylococcus aureus strain 55-99-44

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: CU118_RS06750
• Protein ID: WP_077446684.1
• Coordinates: 1351557..1351733 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1351426..1351565 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CU118_RS06695	1346995..1347174	+	180	WP_000669789.1	hypothetical protein	-
CU118_RS06705	1347485..1347745	+	261	WP_001791826.1	hypothetical protein	-
CU118_RS06710	1347798..1348148	-	351	WP_000702262.1	complement inhibitor SCIN-A	-
CU118_RS06715	1348657..1348992	-	336	Protein_1283	SH3 domain-containing protein	-
CU118_RS06730	1349642..1350133	-	492	WP_000919350.1	staphylokinase	-
CU118_RS06735	1350324..1351079	-	756	WP_000861038.1	CHAP domain-containing protein	-
CU118_RS06740	1351091..1351345	-	255	WP_000611512.1	phage holin	-
CU118_RS06745	1351397..1351504	+	108	WP_001791821.1	hypothetical protein	-
-	1351426..1351565	+	140	NuclAT_0	-	Antitoxin
-	1351426..1351565	+	140	NuclAT_0	-	Antitoxin
-	1351426..1351565	+	140	NuclAT_0	-	Antitoxin
-	1351426..1351565	+	140	NuclAT_0	-	Antitoxin
CU118_RS06750	1351557..1351733	-	177	WP_077446684.1	putative holin-like toxin	Toxin
CU118_RS06755	1351885..1352196	-	312	WP_054190602.1	DUF2951 family protein	-
CU118_RS06760	1352254..1352541	-	288	WP_001040261.1	hypothetical protein	-
CU118_RS06765	1352588..1352740	-	153	WP_001153681.1	hypothetical protein	-
CU118_RS06770	1352730..1356515	-	3786	WP_100793822.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / sak / lukD / hlgA	1347798..1410384	62586

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6844.44 Da
• Isoelectric Point: 9.9479

>T89433 WP_077446684.1 NZ_CP024998:c1351733-1351557 [Staphylococcus aureus]
MDRWWLSEYKEVVPMLALLKSLERRCLMITISTMLQFGLFLIALIGLVIKFIELSNKK

Nucleotide

• Length: 177 bp

>T89433 NZ_CP024998:c1351733-1351557 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGTTGGCATTACTGAAATCTTTAGAAAGGAGATGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGTTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 140 bp

>AT89433 NZ_CP024998:1351426-1351565 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Antitoxin