Detailed information of TA system TA089427

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1007025..1007604
• Replicon: chromosome
• Accession: NZ_CP024998
• Organism: Staphylococcus aureus strain 55-99-44

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: CU118_RS04950
• Protein ID: WP_001025401.1
• Coordinates: 1007359..1007604 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1007025..1007390 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CU118_RS04910	1003768..1004325	-	558	WP_000645042.1	DUF2815 family protein	-
CU118_RS04915	1004351..1005517	-	1167	WP_000762547.1	DUF2800 domain-containing protein	-
CU118_RS04920	1005514..1005876	-	363	WP_000985984.1	hypothetical protein	-
CU118_RS04925	1005891..1006214	-	324	WP_000175001.1	hypothetical protein	-
CU118_RS04930	1006293..1006454	-	162	WP_001285954.1	DUF1270 domain-containing protein	-
CU118_RS04935	1006467..1006730	-	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
CU118_RS04940	1006755..1006970	-	216	WP_001097552.1	hypothetical protein	-
CU118_RS04945	1007025..1007390	+	366	WP_001128433.1	hypothetical protein	Antitoxin
CU118_RS04950	1007359..1007604	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
CU118_RS04955	1007660..1007869	+	210	WP_000642492.1	hypothetical protein	-
CU118_RS04960	1007859..1008002	-	144	WP_000939498.1	hypothetical protein	-
CU118_RS04965	1008031..1008807	-	777	WP_001148544.1	Rha family transcriptional regulator	-
CU118_RS04970	1008821..1009057	-	237	WP_001121027.1	helix-turn-helix domain-containing protein	-
CU118_RS04975	1009209..1009523	+	315	WP_000333630.1	helix-turn-helix domain-containing protein	-
CU118_RS04980	1009536..1009997	+	462	WP_000525004.1	hypothetical protein	-
CU118_RS04985	1010015..1010449	+	435	WP_000755718.1	hypothetical protein	-
CU118_RS04990	1010478..1010873	+	396	WP_000449655.1	hypothetical protein	-
CU118_RS04995	1010963..1011109	+	147	WP_001795334.1	hypothetical protein	-
CU118_RS05000	1011106..1011720	-	615	WP_000191466.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	lukF-PV / lukS-PV	964440..1030690	66250

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T89427 WP_001025401.1 NZ_CP024998:c1007604-1007359 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T89427 NZ_CP024998:c1007604-1007359 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT89427 NZ_CP024998:1007025-1007390 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin